膳食模式与龈下微生物群之间的关系:口腔感染、葡萄糖不耐受和胰岛素抵抗研究(ORIGINS)的结果

IF 5.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Rebecca L. Molinsky, Abigail J. Johnson, Lisa Marotz, Sumith Roy, Bruno Bohn, Charlene E. Goh, Ching‐Yuan Chen, Bruce Paster, Rob Knight, Jeanine Genkinger, Panos N. Papapanou, David R. Jacobs, Ryan T. Demmer
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Demmer","doi":"10.1111/jcpe.14067","DOIUrl":null,"url":null,"abstract":"ObjectiveTo study the association between dietary patterns and subgingival microbiota.MethodsParticipants (<jats:italic>n</jats:italic> = 651) who were enrolled in the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) with subgingival plaque sampling (<jats:italic>n</jats:italic> = 890 plaques) and a dietary assessment were included. 16S rRNA gene amplicon sequences of subgingival plaque from sites with either probing depth &lt;4 or ≥4 mm were processed separately and used to obtain α‐diversity metrics (Faith, Shannon, Simpson, Observed) and taxa ratios (<jats:italic>Red Complex</jats:italic> to <jats:italic>Corynebacterium</jats:italic> [RCLR], <jats:italic>Treponema to Corynebacterium</jats:italic> [TCLR], and <jats:italic>Treponema to Neisseria</jats:italic> [TNLR]). Food frequency questionnaires (FFQs) were processed to calculate Alternate Healthy Eating Index (AHEI) and A Priori Diet Quality Score (APDQS) scores. Mixed regression models examined the mean levels of microbial metrics across quartiles of diet quality. Means ± standard errors are reported along with <jats:italic>p</jats:italic>‐values.ResultsIn multivariable models assessing the association between diet scores and α‐diversity metrics, higher AHEI values were significantly associated with lower Faith (<jats:italic>p</jats:italic>‐value = 0.01) and Observed (<jats:italic>p</jats:italic>‐value = 0.04) diversity values; similar findings were observed for APDQS (<jats:italic>p</jats:italic>‐value = 0.01, <jats:italic>p</jats:italic>‐value = 0.04). In multivariable models assessing the association between diet scores (AHEI and APDQS) and taxa ratios (RCLR, TCLR and TNLR), as the AHEI quartile increased, all taxa ratios decreased significantly as follows: −1.06 ± 0.093 in Q1 to −1.34 ± 0.099 in Q4 (RCLR), −0.43 ± 0.077 in Q1 to −0.64 ± 0.083 in Q4 (TCLR) and −0.09 ± 0.083 in Q1 to −0.38 ± 0.089 in Q4 (TNLR), respectively. 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引用次数: 0

摘要

方法纳入参加口腔感染、葡萄糖不耐受和胰岛素抵抗研究(ORIGINS)并进行龈下菌斑采样(890 个菌斑)和饮食评估的参与者(n = 651)。对探查深度为 4 毫米或≥4 毫米的龈下斑块的 16S rRNA 基因扩增片段序列分别进行处理,并用于获得 α 多样性指标(费斯、香农、辛普森、观察)和类群比(红色复合菌与棒状杆菌 [RCLR]、特雷波菌与棒状杆菌 [TCLR] 和特雷波菌与奈瑟菌 [TNLR])。对食物频率问卷(FFQ)进行处理,以计算替代健康饮食指数(AHEI)和先验饮食质量评分(APDQS)。混合回归模型检验了膳食质量四分位数中微生物指标的平均水平。结果在评估饮食评分与 α 多样性指标之间关系的多变量模型中,AHEI 值越高,信仰值(p-value = 0.01)和观察值(p-value = 0.04)越低;APDQS 也有类似结果(p-value = 0.01,p-value = 0.04)。在评估膳食评分(AHEI 和 APDQS)与分类群比率(RCLR、TCLR 和 TNLR)之间关系的多变量模型中,随着 AHEI 四分位数的增加,所有分类群比率均显著下降,具体情况如下:从第一季度的-1.06 ± 0.093 到第四季度的-1.34 ± 0.099(RCLR),从第一季度的-0.43 ± 0.077 到第四季度的-0.64 ± 0.083(TCLR),从第一季度的-0.09 ± 0.083 到第四季度的-0.38 ± 0.089(TNLR)。相比之下,随着 APDQS 四分位数的增加,只有 TNLR 从第一季度的 -0.08 ± 0.085 显著下降到第四季度的 -0.34 ± 0.091。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS)
ObjectiveTo study the association between dietary patterns and subgingival microbiota.MethodsParticipants (n = 651) who were enrolled in the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) with subgingival plaque sampling (n = 890 plaques) and a dietary assessment were included. 16S rRNA gene amplicon sequences of subgingival plaque from sites with either probing depth <4 or ≥4 mm were processed separately and used to obtain α‐diversity metrics (Faith, Shannon, Simpson, Observed) and taxa ratios (Red Complex to Corynebacterium [RCLR], Treponema to Corynebacterium [TCLR], and Treponema to Neisseria [TNLR]). Food frequency questionnaires (FFQs) were processed to calculate Alternate Healthy Eating Index (AHEI) and A Priori Diet Quality Score (APDQS) scores. Mixed regression models examined the mean levels of microbial metrics across quartiles of diet quality. Means ± standard errors are reported along with p‐values.ResultsIn multivariable models assessing the association between diet scores and α‐diversity metrics, higher AHEI values were significantly associated with lower Faith (p‐value = 0.01) and Observed (p‐value = 0.04) diversity values; similar findings were observed for APDQS (p‐value = 0.01, p‐value = 0.04). In multivariable models assessing the association between diet scores (AHEI and APDQS) and taxa ratios (RCLR, TCLR and TNLR), as the AHEI quartile increased, all taxa ratios decreased significantly as follows: −1.06 ± 0.093 in Q1 to −1.34 ± 0.099 in Q4 (RCLR), −0.43 ± 0.077 in Q1 to −0.64 ± 0.083 in Q4 (TCLR) and −0.09 ± 0.083 in Q1 to −0.38 ± 0.089 in Q4 (TNLR), respectively. In contrast, as the APDQS quartiles increased, only TNLR decreased significantly from −0.08 ± 0.085 in Q1 to −0.34 ± 0.091 in Q4.ConclusionDiets rich in fruits, vegetables, whole grains and other nutritionally rich plant foods are associated with lower oral microbial diversity and favourable ratios of pathogenic to commensal microbiota.
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来源期刊
Journal of Clinical Periodontology
Journal of Clinical Periodontology 医学-牙科与口腔外科
CiteScore
13.30
自引率
10.40%
发文量
175
审稿时长
3-8 weeks
期刊介绍: Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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