针对含 PWWP 结构域蛋白的抑制剂

IF 6 2区医学 Q1 CHEMISTRY, MEDICINAL

European Journal of Medicinal Chemistry Pub Date : 2024-10-12 DOI:10.1016/j.ejmech.2024.116965

Yunyuan Huang , Boyi Li , Zhibin Wu , Ke Liu, Jinrong Min

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引用次数: 0

摘要

含 PWWP 结构域的蛋白质在染色质介导的生物过程中发挥着关键作用，它们的异常调控与多种人类疾病有关。近年来，人们在揭示含 PWWP 结构域蛋白的结构和功能特征方面取得了长足进步，推动了以含 PWWP 结构域蛋白为靶点的药物研发取得了重大进展。有几种药物已经获得批准，还有一些药物正在进行临床试验。本综述全面概述了含 PWWP 结构域蛋白质的最新进展，包括其结构特征和生物学意义。它还详细介绍了针对这些蛋白质的药物发现过程，包括筛选、设计和结构优化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inhibitors targeting the PWWP domain-containing proteins

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Inhibitors targeting the PWWP domain-containing proteins

PWWP domain-containing proteins play a pivotal role in chromatin-mediated biological processes, and their aberrant regulation is linked to various human diseases. Recent years have witnessed remarkable strides in unraveling the structural and functional features of PWWP domain-containing proteins, propelling significant advances in targeting the PWWP domain-containing proteins for drug discovery purposes. Several drugs have already been approved, while others are currently in clinical trials. This review offers a comprehensive overview of the latest developments on PWWP domain-containing proteins, including their structural characteristics and biological significance. It also provides detailed insights into the drug discovery process targeting these proteins, including screening, design, and structural optimization.

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来源期刊

European Journal of Medicinal Chemistry 化学-医药化学

CiteScore

11.70

自引率

9.00%

发文量

863

审稿时长

29 days

期刊介绍： The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.