在室温下保存 15 年的二硝基苄基铁与谷胱甘肽络合物（Oxacom）冻干药物的降血压活性保存情况

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2024-09-27 DOI:10.1134/S0006350924700362

A. F. Vanin, A. A. Abramov, A. A. Timoshin, V. L. Lakomkin, N. A. Tkachev

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引用次数: 0

摘要

冷冻干燥药物 Oxacom 在室温下抽出空气后在容器中储存 15 年后，其抗高血压活性得以完全保存；这是因为这种药物中存在二亚硝基铁与谷胱甘肽的双核形式络合物。有人提出，二亚硝基铁络合物成分中的谷胱甘肽配体被逐渐渗入容器的空气氧化，可能导致这些络合物的分解，而这种药物中大量的游离谷胱甘肽（不包括在二亚硝基铁络合物中）防止了这种氧化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preservation of Hypotensive Activity in Freeze-Dried Drugs of Dinitrozyl Iron Complexes with Glutathione (Oxacom) Stored for 15 Years at Room Temperature

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Preservation of Hypotensive Activity in Freeze-Dried Drugs of Dinitrozyl Iron Complexes with Glutathione (Oxacom) Stored for 15 Years at Room Temperature

Complete preservation of the antihypertensive activity of the freeze-dried drug Oxacom has been demonstrated after storing it for 15 years at room temperature in vessels with the air pumped out; this is due to the presence of a binuclear form of a dinitrosyl iron complex with glutathione in this drug. It was proposed that the oxidation of glutathione ligands in the composition of dinitrosyl iron complexes by air gradually penetrating into the vessels, which could lead to the decomposition of these complexes, was prevented by a significant amount of free (not included in dinitrosyl iron complexes) glutathione in this drug.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.