MKRN 蛋白家族中与 RNA 结合的泛素连接酶分子功能的多样性

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ekaterina A. Guseva, Maria A. Emelianova, Vera N. Sidorova, Anatoly N. Tyulpakov, Olga A. Dontsova, Petr V. Sergiev
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引用次数: 0

摘要

Makorin RING 手指蛋白家族包括四个成员(MKRN1、MKRN2、MKRN3 和 MKRN4),它们属于 E3 泛素连接酶,在细胞存活、细胞分化、先天和适应性免疫等各种生物过程中发挥着关键作用。MKRN1 有助于抑制肿瘤生长、能量代谢、抗病原体防御和细胞凋亡,其靶标种类繁多,包括 hTERT、APC、FADD、p21 和各种病毒蛋白。MKRN2 可调节细胞增殖、炎症反应;其靶标包括 p65、PKM2、STAT1 和其他蛋白。MKRN3 是青春期时间的主调节器;它控制着弓状核神经元中促性腺激素释放激素的水平。MKRN4 是 MKRN 蛋白家族中研究最少的成员,但已知它通过泛素化丝氨酸/苏氨酸激酶 MAP4K3 来促进 T 细胞的活化。MKRN家族蛋白与许多疾病的发生有关,例如系统性红斑狼疮、中枢性性早熟、普拉德-威利综合征、退行性腰椎管狭窄症、炎症和癌症。在这篇综述中,我们将讨论 MKRN 蛋白家族所有成员的功能作用及其在疾病发展中的参与。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diversity of Molecular Functions of RNA-Binding Ubiquitin Ligases from the MKRN Protein Family

Makorin RING finger protein family includes four members (MKRN1, MKRN2, MKRN3, and MKRN4) that belong to E3 ubiquitin ligases and play a key role in various biological processes, such as cell survival, cell differentiation, and innate and adaptive immunity. MKRN1 contributes to the tumor growth suppression, energy metabolism, anti-pathogen defense, and apoptosis and has a broad variety of targets, including hTERT, APC, FADD, p21, and various viral proteins. MKRN2 regulates cell proliferation, inflammatory response; its targets are p65, PKM2, STAT1, and other proteins. MKRN3 is a master regulator of puberty timing; it controls the levels of gonadotropin-releasing hormone in the arcuate nucleus neurons. MKRN4 is the least studied member of the MKRN protein family, however, it is known to contribute to the T cell activation by ubiquitination of serine/threonine kinase MAP4K3. Proteins of the MKRN family are associated with the development of numerous diseases, for example, systemic lupus erythematosus, central precocious puberty, Prader–Willi syndrome, degenerative lumbar spinal stenosis, inflammation, and cancer. In this review, we discuss the functional roles of all members of the MKRN protein family and their involvement in the development of diseases.

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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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