通用适配蛋白 Bag3 和小型热休克蛋白

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Maria A. Zamotina, Lidia K. Muranova, Artur I. Zabolotskii, Pyotr A. Tyurin-Kuzmin, Konstantin Yu. Kulebyakin, Nikolai B. Gusev
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引用次数: 0

摘要

Bag3(Bcl-2-associated athanogene 3)蛋白含有多个功能域,可与多种不同的伙伴蛋白相互作用,其中包括小型热休克蛋白(sHsps)和热休克蛋白 Hsp70。Bag3-sHsp 和 Hsp70 的三元复合物可结合变性蛋白质并将其转运到吞噬体,从而在伴侣辅助选择性自噬(CASA)中发挥关键作用。该复合物还参与控制应激颗粒的形成和解体(颗粒停滞)以及细胞骨架调节。由于 Bag3 和 sHsps 参与多种细胞过程,这些蛋白的突变往往与神经退行性疾病和心肌病有关。本综述讨论了 sHsps 在 Bag3 调节的不同过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Universal Adapter Protein Bag3 and Small Heat Shock Proteins

Bag3 (Bcl-2-associated athanogene 3) protein contains a number of functional domains and interacts with a wide range of different partner proteins, including small heat shock proteins (sHsps) and heat shock protein Hsp70. The ternary Bag3–sHsp–and Hsp70 complex binds denatured proteins and transports them to phagosomes, thus playing a key role in the chaperone-assisted selective autophagy (CASA). This complex also participates in the control of formation and disassembly of stress granules (granulostasis) and cytoskeleton regulation. As Bag3 and sHsps participate in multiple cellular processes, mutations in these proteins are often associated with neurodegenerative diseases and cardiomyopathy. The review discusses the role of sHsps in different processes regulated by Bag3.

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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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