氚标记地塞米松磷酸酯的制备及其在评估配体对糖皮质激素受体亲和力中的应用

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Radiochemistry Pub Date : 2024-10-06 DOI:10.1134/S1066362224040131

G. A. Badun, E. M. Zhidkova, M. G. Chernysheva, A. D. Enikeev, M. G. Yakubovskaya, E. A. Lesovaya

引用次数: 0

摘要

利用热活化法在地塞米松和地塞米松磷酸盐中引入氚的可能性得到了证实。利用标记化合物成功评估了配体与糖皮质激素受体的亲和力。

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Preparation of Tritium Labeled Dexamethasone Phosphate and Its Application to Assess the Affinity of Ligands for Glucocorticoid Receptors

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Preparation of Tritium Labeled Dexamethasone Phosphate and Its Application to Assess the Affinity of Ligands for Glucocorticoid Receptors

The possibility of introducing tritium into dexamethasone and dexamethasone phosphate using the thermal activation method was demonstrated. The affinity of ligands for glucocorticoid receptors has been successfully assessed using labeled compounds.

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.