S. Alghamdi, N. F. Qusty, B. Atwah, Z. Alhindi, R. Alatawy, S. Verma, M. Asif
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Isoniazid Analogs and Their Biological Activities as Antitubercular Agents (A Review)
Tuberculosis (TB), which has been a scourge of humanity for thousands of years, is a worldwide pandemic disease caused mainly by M. tuberculosis (Mtb). The appearance of TB and the emergence of drug resistance (DR) requires focused attention and the need to approve the various isoniazid (INH) analogs. The DR-TB, multidrug resistance (MDR), extensively drug-resistant (XDR), and totally drug-resistant (TDR) TB increase the challenges to eliminate TB globally. INH is an important heterocyclic moiety in medicinal chemistry due to the presence of an active site, which extends its applications and is a frontline key anti-TB drug. In this review, we aim to summarize synthetic strategies and pharmacological properties of INH analogs and we also discussed INH analogs as potent anti-TB agents. This review summarized the recent advances of anti-TB agents holding INH as a nucleus. Data on collection of various INH analogs and their biological activities like anti-TB, antibacterial, antifungal, antiviral, etc. were presented.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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