Subham Preetam, Arka Ghosh, Richa Mishra, Arunima Pandey, Debanjan Singha Roy, Sarvesh Rustagi and Sumira Malik
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引用次数: 0
摘要
电刺激(ES)已成为促进生物伤口愈合的一种强有力的治疗方式。这种非侵入性技术利用低水平电流促进组织再生,加快伤口愈合过程。研究表明,ES 能通过各种机制加速伤口闭合、减少炎症、促进血管生成以及调节细胞迁移和增殖。伤口处理的主要目标是迅速恢复皮肤解剖学上的连续性,防止外部环境的感染并维持内部的平衡状态。在伤口部位使用 ES 是一种令人信服的皮肤伤口修复策略。医学文献中描述了多种 ES 应用,如交流、直流和 PC,以改善皮肤灌注并加速伤口愈合。本综述旨在评估主要因素,并概述 ES 在伤口愈合中的潜在益处和机制,及其刺激细胞反应、促进组织再生和改善整体愈合效果的能力。我们还对 ES 的应用进行了阐述,ES 作为一种辅助疗法在治疗各种类型的伤口(包括慢性伤口、糖尿病溃疡和手术切口)方面前景广阔。
Electrical stimulation: a novel therapeutic strategy to heal biological wounds
Electrical stimulation (ES) has emerged as a powerful therapeutic modality for enhancing biological wound healing. This non-invasive technique utilizes low-level electrical currents to promote tissue regeneration and expedite the wound healing process. ES has been shown to accelerate wound closure, reduce inflammation, enhance angiogenesis, and modulate cell migration and proliferation through various mechanisms. The principle goal of wound management is the rapid recovery of the anatomical continuity of the skin, to prevent infections from the external environment and maintain homeostasis conditions inside. ES at the wound site is a compelling strategy for skin wound repair. Several ES applications are described in medical literature like AC, DC, and PC to improve cutaneous perfusion and accelerate wound healing. This review aimed to evaluate the primary factors and provides an overview of the potential benefits and mechanisms of ES in wound healing, and its ability to stimulate cellular responses, promote tissue regeneration, and improve overall healing outcomes. We also shed light on the application of ES which holds excellent promise as an adjunct therapy for various types of wounds, including chronic wounds, diabetic ulcers, and surgical incisions.
期刊介绍:
An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.