9R 鸡伤寒减毒活疫苗对鹧鸪的安全性和有效性。

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2024-10-11 DOI:10.1016/j.vaccine.2024.126413

Zohra Bamouh , Noha Semmate , Mohamed Mouahid , Ismail Kerbal , Khalid Omari Tadlaoui , Mehdi Elharrak

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引用次数: 0

摘要

鸡伤寒是世界范围内一种重要的禽类疾病，主要影响鸡、火鸡和鹧鸪等其他鸟类。在摩洛哥，这种疾病导致养殖的鹧鸪死亡率很高。鹧鸪疫苗接种是保护鹧鸪品种的当务之急，但该疫苗从未在这一物种中进行过评估。这项研究旨在评估当地生产的沙门氏菌 9R 活疫苗对鹧鸪的安全性和有效性。各组接种疫苗的鹧鸪在 6 周龄时接种疫苗，6 周后进行第二次注射。在 14 周时进行胆沙门氏菌 MSG1 毒株挑战试验。与未接种疫苗的对照组相比，接种过疫苗的鹌鹑的保护率为 65%，器官侵袭率降低，死亡率为 70.6%。9R 减毒活疫苗可安全用于减少鸟群损失，并有助于减少感染。

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Safety and efficacy of 9R live attenuated vaccine against fowl typhoid in partridge's species

Fowl typhoid is a significant avian disease worldwide affecting mainly chickens, turkeys and other bird species, such as partridges. In Morocco, the disease causes a high mortality rate in farmed partridges. Vaccination of partridges is a priority to preserve the breed however; the vaccine has never been evaluated in this species. The study was conducted to assess safety and efficacy of a locally produced Salmonella 9R live vaccine in partridges.

Groups of vaccinated partridges received the vaccine at 6 weeks of age, followed by a second injection 6 weeks after. The challenge test was performed at 14 weeks with Salmonella gallinarum MSG1 virulent strain.

The challenge demonstrated 65 % protection in vaccinated challenged partridges, with a reduction in organ invasion compared to unvaccinated control birds, which exhibited 70,6 % mortality.

The live attenuated 9R vaccine, could be safely used to reduce flock losses and contribute to the reduction of infection.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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