光电化学生物传感器：基于氮化石墨的传感器在前列腺特异性抗原诊断中的应用前景。

IF 2.6 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Analytical biochemistry Pub Date : 2024-10-10 DOI:10.1016/j.ab.2024.115686

Seyed Saman Nemati, Gholamreza Dehghan

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引用次数: 0

摘要

前列腺癌（PCs）在老年人中非常常见，并导致许多人死亡。早期诊断、监测疾病进展和癌症治疗效果至关重要。另一方面，选择前列腺癌的特异性生物标记物也至关重要。前列腺特异性抗原（PSA）是前列腺上皮细胞分泌的一种特异性生物标志物，在癌细胞中会增加。在所有采用的传感机制中，基于纳米材料的电化学传感器给人们带来了许多希望。与此同时，氮化石墨（g-C3N4）因其比表面积大、稳定性好、易于改性和良好的光电特性而在光电化学传感器的开发中备受关注。本综述研究了基于含 g-C3N4 纳米复合材料的电化学传感器在 PSA 检测中的应用。在概述了 g-C3N4 和癌症生物标记物的特性之后，本综述回顾了识别 PSA 所涉及的策略和机制。诊断机制采用了光电化学、阻抗免疫传感器、光催化和发光等不同方法。然后，分析了基于含 g-C3N4 纳米复合材料的电化学传感器在 PSA 检测中面临的挑战和前景。最近的综述总体上为 PSA 诊断以及基于 g-C3N4 的电化学传感器在个性化医学诊断和治疗中的应用开辟了一条有效的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoelectrochemical biosensors: Prospects of graphite carbon nitride-based sensors in prostate-specific antigen diagnosis

查看原文本刊更多论文

Photoelectrochemical biosensors: Prospects of graphite carbon nitride-based sensors in prostate-specific antigen diagnosis

Prostate cancer (PC) is very common in old age and causes many deaths. Early diagnosis and monitoring of the progress of the disease and the effectiveness of PC treatment are critical. On the other hand, choosing a specific biomarker for PCs is essential. Prostate-specific antigen (PSA) is a specific biomarker secreted in the prostate epithelial cells, which increases in cancer cells. Between all employed sensing mechanism, electrochemical sensors based on nanomaterials have created many hopes. Meanwhile, graphite carbon nitride (g-C₃N₄) is interested in developing photoelectrochemical sensors due to its large surface area, stability, easy modification, and good photoelectronic properties. In this review, electrochemical sensors based on nanocomposites containing g-C₃N₄ have been investigated in PSA detection. After providing an overview of the characteristics of g-C₃N₄ and cancer biomarkers, it reviews the strategies and mechanisms involved in identifying PSA. Different approaches to photoelectrochemistry, impedimetric immunosensors, photocatalysis, and luminescence have been used in diagnostic mechanisms. Then, challenges and prospects for electrochemical sensors based on nanocomposites containing g-C₃N₄ in PSA detection have been analyzed. The recent review generally opens an efficient view in PSA diagnosis and the application of g–C₃N₄–based electrochemical sensors in personalized medicine diagnosis and treatment.

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来源期刊

Analytical biochemistry 生物-分析化学

CiteScore

5.70

自引率

0.00%

发文量

283

审稿时长

44 days

期刊介绍： The journal''s title Analytical Biochemistry: Methods in the Biological Sciences declares its broad scope: methods for the basic biological sciences that include biochemistry, molecular genetics, cell biology, proteomics, immunology, bioinformatics and wherever the frontiers of research take the field. The emphasis is on methods from the strictly analytical to the more preparative that would include novel approaches to protein purification as well as improvements in cell and organ culture. The actual techniques are equally inclusive ranging from aptamers to zymology. The journal has been particularly active in: -Analytical techniques for biological molecules- Aptamer selection and utilization- Biosensors- Chromatography- Cloning, sequencing and mutagenesis- Electrochemical methods- Electrophoresis- Enzyme characterization methods- Immunological approaches- Mass spectrometry of proteins and nucleic acids- Metabolomics- Nano level techniques- Optical spectroscopy in all its forms. The journal is reluctant to include most drug and strictly clinical studies as there are more suitable publication platforms for these types of papers.