近视性黄斑病变的进展:对后葡萄膜瘤和黄斑受累的认识.....:简称:近视性黄斑病变的进展。

IF 4.1 1区 医学 Q1 OPHTHALMOLOGY
Ignacio Flores-Moreno , Mariluz Puertas , Marina Fernández-Jiménez , Luis Celestino Franco , María Terrón-Vilalta , Blanca Eslava , Elena Almazán-Alonso , Jorge Ruiz-Medrano , Bachar Kudsieh , María García-Zamora , José M. Ruiz-Moreno
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引用次数: 0

摘要

目的:分析近视性黄斑病变的发展模式:方法:在 Puerta de Hierro-Majadahonda 大学医院(西班牙马德里)对 430 名患者的 824 只高度近视眼(轴向长度≥26 毫米)进行检查,随访至少 2 年。所有患者都接受了全面的眼科检查,包括多模态成像。根据ATN分类系统评估了基线和整个随访期间近视性黄斑病变的进展情况以及相关的临床特征:在平均4.10±1.28(范围:2.00至6.23)年的随访期间,42%的眼睛出现近视性黄斑病变进展。与未进展的眼睛相比,近视黄斑病变的进展与随访时最佳矫正视力(BCVA)的恶化有关(P0.05)。患有后葡萄膜瘤(PS)的眼睛,尤其是患有黄斑部葡萄膜瘤的眼睛,近视性黄斑病变的进展程度明显更高(P结论:该研究强调了近视性黄斑病变在自然病程中的显著进展,随着黄斑并发症的进展,BCVA 也会受到影响。近视性黄斑病变的进展与PS明显相关,特别是与黄斑受累者明显相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Myopic Maculopathy Progression: Insights Into Posterior Staphyloma and Macular Involvement

PURPOSE

To analyze myopic maculopathy's progression pattern.

DESIGN

Retrospective, observational case series.

METHODS

A total of 824 highly myopic eyes (axial length ≥26 mm) of 430 patients examined at Puerta de Hierro-Majadahonda University Hospital (Madrid, Spain) with a minimum follow-up of 2 years. All patients underwent complete ophthalmologic examination, including multimodal imaging. Progression of myopic maculopathy was assessed according to ATN classification system at baseline and throughout the follow-up, as well as associated clinical features.

RESULTS

Progression of myopic maculopathy was described in 42% of eyes over a mean follow-up of 4.10 ± 1.28 (range, 2.00-6.23) years. Compared with nonprogressing eyes, myopic maculopathy progression correlated with worse best-corrected visual acuity (BCVA) at follow-up (P < .05) and greater BCVA loss (P < .01). There were no significant differences between groups in axial length, gender, and age (P > .05). Eyes with posterior staphyloma (PS) and, particularly, those with macular PS showed significantly greater myopic maculopathy progression (P < .01). The likelihood of myopic maculopathy's progression was 3.94 times higher (odds ratio, 3.94 ± 1.22, P < .01) in eyes with PS compared with those without PS. Atrophic progression occurred in 21.9% of eyes, with diffuse to patchy atrophy being the most common pattern (54.17%). Tractional progression was observed in 22.8% of eyes, predominantly from nontraction to inner/outer foveoschisis (40%). Neovascular progression affected 11.4% of the eyes, most of them from no neovascular component to macular lacquer cracks (40%).

CONCLUSIONS

This study highlights significant myopic maculopathy progression over the natural course of the disease, compromising the BCVA as macular complications progress. Myopic maculopathy progression was significantly associated with PS, especially in those with macular involvement.
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来源期刊
CiteScore
9.20
自引率
7.10%
发文量
406
审稿时长
36 days
期刊介绍: The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.
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