Zhihao Zhang, Huaiwen Cang, Wei Huang, Hang Li, Haiyang Li
{"title":"通过微型热电冷却脱水耦合现场测量呼出丙酮的光离子化离子迁移率分析仪","authors":"Zhihao Zhang, Huaiwen Cang, Wei Huang, Hang Li, Haiyang Li","doi":"10.1016/j.snb.2024.136743","DOIUrl":null,"url":null,"abstract":"The breath concentration of acetone holds significant clinical importance, the development of on-site and accurate analyzer for exhaled acetone is highly demanded. A photoionization ion mobility analyzer based on a low-pressure krypton discharge lamp has been developed for direct and rapid determination of the acetone concentration. The difficulty for sensitive measurement of acetone by vacuum ultraviolet photoionization was the strong absorption of water molecules in the breath air. An online dehydration device with a miniature thermoelectric cooling quartz trap has been developed, which was capable for reducing the relative humidity from over 90% to below 1%. The dehydration could enhance the signal intensity of acetone about 85 times. The response time of current thermoelectric cooling dehydration was only 1/20 of the Nafion tube dehydration. A limit of detection 0.02 ppm<sub>V</sub> and linear response up to 2.0 ppm<sub>V</sub> were achieved. The interferences from ammonia in exhaled breath was eliminated using a calibration method based on ion number density, achieving recoveries ranging from 90% to 110%. In the final, the variation trends of exhaled acetone level in healthy individuals following the ingestion of glucose under fasting conditions were carried out to demonstrate the potential application of the analyzer.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photoionization Ion Mobility Analyzer for On-site Measurement of Exhaled Acetone by Coupling Miniature Thermoelectric Cooling Dehydration\",\"authors\":\"Zhihao Zhang, Huaiwen Cang, Wei Huang, Hang Li, Haiyang Li\",\"doi\":\"10.1016/j.snb.2024.136743\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The breath concentration of acetone holds significant clinical importance, the development of on-site and accurate analyzer for exhaled acetone is highly demanded. A photoionization ion mobility analyzer based on a low-pressure krypton discharge lamp has been developed for direct and rapid determination of the acetone concentration. The difficulty for sensitive measurement of acetone by vacuum ultraviolet photoionization was the strong absorption of water molecules in the breath air. An online dehydration device with a miniature thermoelectric cooling quartz trap has been developed, which was capable for reducing the relative humidity from over 90% to below 1%. The dehydration could enhance the signal intensity of acetone about 85 times. The response time of current thermoelectric cooling dehydration was only 1/20 of the Nafion tube dehydration. A limit of detection 0.02 ppm<sub>V</sub> and linear response up to 2.0 ppm<sub>V</sub> were achieved. The interferences from ammonia in exhaled breath was eliminated using a calibration method based on ion number density, achieving recoveries ranging from 90% to 110%. In the final, the variation trends of exhaled acetone level in healthy individuals following the ingestion of glucose under fasting conditions were carried out to demonstrate the potential application of the analyzer.\",\"PeriodicalId\":425,\"journal\":{\"name\":\"Sensors and Actuators B: Chemical\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.0000,\"publicationDate\":\"2024-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sensors and Actuators B: Chemical\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.snb.2024.136743\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensors and Actuators B: Chemical","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.snb.2024.136743","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Photoionization Ion Mobility Analyzer for On-site Measurement of Exhaled Acetone by Coupling Miniature Thermoelectric Cooling Dehydration
The breath concentration of acetone holds significant clinical importance, the development of on-site and accurate analyzer for exhaled acetone is highly demanded. A photoionization ion mobility analyzer based on a low-pressure krypton discharge lamp has been developed for direct and rapid determination of the acetone concentration. The difficulty for sensitive measurement of acetone by vacuum ultraviolet photoionization was the strong absorption of water molecules in the breath air. An online dehydration device with a miniature thermoelectric cooling quartz trap has been developed, which was capable for reducing the relative humidity from over 90% to below 1%. The dehydration could enhance the signal intensity of acetone about 85 times. The response time of current thermoelectric cooling dehydration was only 1/20 of the Nafion tube dehydration. A limit of detection 0.02 ppmV and linear response up to 2.0 ppmV were achieved. The interferences from ammonia in exhaled breath was eliminated using a calibration method based on ion number density, achieving recoveries ranging from 90% to 110%. In the final, the variation trends of exhaled acetone level in healthy individuals following the ingestion of glucose under fasting conditions were carried out to demonstrate the potential application of the analyzer.
期刊介绍:
Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.