Wang Zheng, Hui Shen, Yuanfang Cheng, Litao Liu, Jiangwei Sun, Zhaoyou Chu*, Wanni Wang* and Haisheng Qian*,
{"title":"金纳米棒激活 Zn2+/Ag+ 介导的抗炎作用，通过仿生爪微针增强耐甲氧西林伤口修复能力","authors":"Wang Zheng, Hui Shen, Yuanfang Cheng, Litao Liu, Jiangwei Sun, Zhaoyou Chu*, Wanni Wang* and Haisheng Qian*, ","doi":"10.1021/acsmaterialslett.4c0154610.1021/acsmaterialslett.4c01546","DOIUrl":null,"url":null,"abstract":"<p >Wound infections caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid–base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core–shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag<sup>+</sup>. Vascular endothelial growth factor expression was promoted by trace Zn<sup>2+</sup>, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn<sup>2+</sup>/Ag<sup>+</sup> and the mild thermal impact showcases new avenues for clinical treatment.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 10","pages":"4791–4800 4791–4800"},"PeriodicalIF":9.6000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Au Nanorods Activate Zn2+/Ag+ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles\",\"authors\":\"Wang Zheng, Hui Shen, Yuanfang Cheng, Litao Liu, Jiangwei Sun, Zhaoyou Chu*, Wanni Wang* and Haisheng Qian*, \",\"doi\":\"10.1021/acsmaterialslett.4c0154610.1021/acsmaterialslett.4c01546\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Wound infections caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid–base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core–shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag<sup>+</sup>. Vascular endothelial growth factor expression was promoted by trace Zn<sup>2+</sup>, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn<sup>2+</sup>/Ag<sup>+</sup> and the mild thermal impact showcases new avenues for clinical treatment.</p>\",\"PeriodicalId\":19,\"journal\":{\"name\":\"ACS Materials Letters\",\"volume\":\"6 10\",\"pages\":\"4791–4800 4791–4800\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2024-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Materials Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c01546\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c01546","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Au Nanorods Activate Zn2+/Ag+ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles
Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid–base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core–shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag+. Vascular endothelial growth factor expression was promoted by trace Zn2+, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn2+/Ag+ and the mild thermal impact showcases new avenues for clinical treatment.
期刊介绍：
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.
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