患有桥本氏甲状腺炎的甲状腺功能正常儿童的前庭功能障碍

Gülcan Seymen, Gözde Günay, Ahmet Adnan Cirik, Reyhan Sürmeli, Mehmet Sürmeli
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摘要

自身免疫性甲状腺疾病与前庭功能障碍之间存在一定关系。本研究旨在分析桥本氏甲状腺炎(HT)患儿和健康对照组之间的颈诱发肌源性电位(cVEMP)和视频头脉冲测试(vHIT)结果,以确定前庭内脏问题。研究人员招募了 36 名桥本氏甲状腺炎患儿和 30 名健康受试者。健康组的主要纳入标准是甲状腺功能正常且无前庭问题临床病史。每位受试者(包括高血压组和健康组)都接受了听觉前庭测试、cVEMP 和 vHIT 评估。就双耳的 cVEMP(p1 和 n1)潜伏期而言,组间无明显差异。两组之间的 cVEMP 振幅(p1-n1 峰峰值)无明显差异。组间左右耳的 VOR 增益差异有统计学意义(P < .001,P < .001)。当我们认为 VOR 增益的较低临界值为 0.80 时,36 名 HT 患者中有 29 人(80.6%)的 VOR 增益得分较低。30 名健康参与者中只有 1 人(3.3%)的 VOR 增益得分较低。这一差异具有统计学意义(P < .001)。HT 患儿可能会出现亚临床前庭病。vHIT 似乎是识别和筛查这类患者临床前前庭病变的重要工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vestibular Dysfunction in Euthyroid Children with Hashimoto's Thyroiditis.

A relationship exists between autoimmune thyroid disorders and vestibular dysfunction. This study aimed to analyze cervicalevoked myogenic potentials (cVEMP) and video head impulse test (vHIT) results between children with Hashimoto thyroiditis (HT) and healthy controls to determine vestibular end-organ problems. Thirty-six children with HT and 30 healthy subjects were recruited. The main inclusion criteria for the healthy group were the presence of normal thyroid function and no clinical history of vestibular problems. Each participant (both HT and healthy groups) was assessed using audiovestibular tests, cVEMP, and vHIT. There was no significant difference between the groups in terms of cVEMP (p1 and n1) latencies for both ears. There was no significant difference in cVEMP amplitudes (p1-n1 peak-to-peak) between the groups. There were statistically significant differences in the VOR gain of the right and left ears between the groups (P < .001, P < .001). When we considered lower cutoff value as 0.80 for VOR gain, 29 of 36 patients with HT (80.6%) had lower VOR gain scores. Only 1 of 30 healthy participants (3.3%) had a lower VOR gain score. This difference was statistically significant (P < .001). Subclinical vestibulopathy may occur in children with HT. The vHIT seems to be a valuable tool for identifying and screening preclinical vestibular pathologies in this patient group.

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