[多血管炎肉芽肿病期间的侵袭性皮肤曲霉病]。

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Revue De Medecine Interne Pub Date : 2024-11-01 DOI:10.1016/j.revmed.2024.09.005

Amir Agade , Cyril Habougit , Cédric Chol , Jean-Baptiste Gaultier , Caroline Mahinc , Lucile Grange , Martin Killian , Baptiste Gramont

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引用次数: 0

摘要

引言曲霉菌病是一种机会性感染，可在任何免疫抑制情况下并发。主要表现为肺部感染，而在严重免疫抑制的情况下，这种感染也可能成为肺外受累的侵袭性感染，这种情况更为罕见：我们报告了一例 76 岁女性患者的病例，她在接受皮质类固醇激素、利妥昔单抗和环磷酰胺治疗后，肉芽肿伴多血管炎复发，并出现弥漫性红斑结节性皮损。经活检和组织学分析，确诊为侵袭性皮肤曲霉菌病。使用伏立康唑治疗后，患者病情好转：结论：接受免疫抑制治疗的患者在炎症背景下出现皮损时，应立即进行全面的微生物学评估，以确定是否存在机会性病原体，并进行皮肤活检，以检查是否存在侵袭性皮肤曲霉菌病。

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Une aspergillose cutanée invasive au cours d’une granulomatose avec polyangéite

Introduction

Aspergillosis is an opportunistic infection that can complicate any situation of immunosuppression. The primary manifestations are pulmonary, and more rarely, in cases of severe immunosuppression, the infection can become invasive with extra-pulmonary involvement.

Observation

We report the case of a 76-year-old female patient, experiencing a relapse of granulomatosis with polyangiitis treated with corticosteroids, rituximab and cyclophosphamide, who presented with diffuse erythematous nodular skin lesions. A biopsy with histological analysis confirmed a diagnosis of invasive cutaneous aspergillosis. Treatment with voriconazole led to a favorable outcome.

Conclusion

The appearance of skin lesions in an inflammatory context in a patient receiving immunosuppressive therapy should prompt a comprehensive microbiological assessment for opportunistic pathogens, as well as a skin biopsy to investigate for invasive cutaneous aspergillosis.

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来源期刊

Revue De Medecine Interne 医学-医学：内科

CiteScore

0.70

自引率

11.10%

发文量

526

审稿时长

37 days

期刊介绍： Official journal of the SNFMI, La revue de medecine interne is indexed in the most prestigious databases. It is the most efficient French language journal available for internal medicine specialists who want to expand their knowledge and skills beyond their own discipline. It is also the main French language international medium for French research works. The journal publishes each month editorials, original articles, review articles, short communications, etc. These articles address the fundamental and innumerable facets of internal medicine, spanning all medical specialties. Manuscripts may be submitted in French or in English. La revue de medecine interne also includes additional issues publishing the proceedings of the two annual French meetings of internal medicine (June and December), as well as thematic issues.