急性乙二醇中毒中的多器官晶体沉积。

IF 1 4区医学 Q3 MEDICINE, LEGAL

American Journal of Forensic Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-10-14 DOI:10.1097/PAF.0000000000000991

Matthew Uy, Kimberley Molina

{"title":"急性乙二醇中毒中的多器官晶体沉积。","authors":"Matthew Uy, Kimberley Molina","doi":"10.1097/PAF.0000000000000991","DOIUrl":null,"url":null,"abstract":"Abstract: Ethylene glycol (EG) is a widely available chemical and a well-known toxin in forensic pathology, which can lead to severe metabolic acidosis and death. Its metabolism in the body leads to formation of calcium oxalate (CO) crystals, which can precipitate in the kidney leading to renal failure. Although the identification of CO crystals in the kidney is widely known, the deposition of CO crystals in other organs has only occasionally been reported and seldom studied. This report examines 18 deaths due to EG toxicity for the presence of CO crystals in various organs. CO crystals were identified most often in the kidneys, followed by the brain and lungs. It is hypothesized that crystal deposition in these other organs may contribute to the toxicity of EG.","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":"44-47"},"PeriodicalIF":1.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multiorgan Crystal Deposition in Acute Ethylene Glycol Toxicity.\",\"authors\":\"Matthew Uy, Kimberley Molina\",\"doi\":\"10.1097/PAF.0000000000000991\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Ethylene glycol (EG) is a widely available chemical and a well-known toxin in forensic pathology, which can lead to severe metabolic acidosis and death. Its metabolism in the body leads to formation of calcium oxalate (CO) crystals, which can precipitate in the kidney leading to renal failure. Although the identification of CO crystals in the kidney is widely known, the deposition of CO crystals in other organs has only occasionally been reported and seldom studied. This report examines 18 deaths due to EG toxicity for the presence of CO crystals in various organs. CO crystals were identified most often in the kidneys, followed by the brain and lungs. It is hypothesized that crystal deposition in these other organs may contribute to the toxicity of EG.\",\"PeriodicalId\":55535,\"journal\":{\"name\":\"American Journal of Forensic Medicine and Pathology\",\"volume\":\" \",\"pages\":\"44-47\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Forensic Medicine and Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/PAF.0000000000000991\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, LEGAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Forensic Medicine and Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/PAF.0000000000000991","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/14 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, LEGAL","Score":null,"Total":0}

引用次数: 0

摘要

摘要：乙二醇（EG）是一种广泛存在的化学品，也是法医病理学中一种众所周知的毒素，可导致严重的代谢性酸中毒和死亡。乙二醇在体内代谢会形成草酸钙（CO）结晶，并在肾脏沉淀，导致肾功能衰竭。虽然在肾脏中发现 CO 晶体已广为人知，但在其他器官中沉积 CO 晶体的情况仅偶有报道，很少进行研究。本报告对 18 例因 EG 中毒死亡的病例进行了检查，以确定各器官中是否存在 CO 晶体。在肾脏中最常发现 CO 晶体，其次是大脑和肺部。据推测，晶体沉积在这些其他器官中可能会导致 EG 的毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Multiorgan Crystal Deposition in Acute Ethylene Glycol Toxicity.

Abstract: Ethylene glycol (EG) is a widely available chemical and a well-known toxin in forensic pathology, which can lead to severe metabolic acidosis and death. Its metabolism in the body leads to formation of calcium oxalate (CO) crystals, which can precipitate in the kidney leading to renal failure. Although the identification of CO crystals in the kidney is widely known, the deposition of CO crystals in other organs has only occasionally been reported and seldom studied. This report examines 18 deaths due to EG toxicity for the presence of CO crystals in various organs. CO crystals were identified most often in the kidneys, followed by the brain and lungs. It is hypothesized that crystal deposition in these other organs may contribute to the toxicity of EG.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American Journal of Forensic Medicine and Pathology 医学-病理学

CiteScore

1.80

自引率

0.00%

发文量

103

审稿时长

4-8 weeks

期刊介绍： Drawing on the expertise of leading forensic pathologists, lawyers, and criminologists, The American Journal of Forensic Medicine and Pathology presents up-to-date coverage of forensic medical practices worldwide. Each issue of the journal features original articles on new examination and documentation procedures. While most articles are available as web based articles, PDF and in ePub reader format, some earlier articles do not have PDFs available. If you would like to view an article in the ePub format, you will need to download an ePub reader to view this file, a number of which are available for free online.