同化-FIT-泌乳素假说:泌乳素在代谢平衡中的作用--关联还是因果关系?

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Jesper Krogh
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引用次数: 0

摘要

泌乳素适应性假说认为,泌乳素在新陈代谢中起着因果作用,低泌乳素血症和高泌乳素血症会导致不良的新陈代谢改变。然而,泌乳素在正常范围内或达到参考上限的四倍,可能是新陈代谢适应的结果,其积极的新陈代谢作用类似于糖尿病前期的胰岛素增加。因此,在这一临界值范围内增加催乳素水平的药物可能具有良好的效果,尤其是对 2 型糖尿病患者。如果泌乳素的代谢作用高于正常阈值,则不仅对糖尿病患者有益,而且有助于决定是否治疗其他患者群体中的轻度高泌乳素血症,如药物诱发的高泌乳素血症或特发性高泌乳素血症。胰腺、肝脏和脂肪组织中都存在催乳素受体,临床前研究表明,催乳素对葡萄糖胰岛素血症和脂质代谢有积极的因果影响。这篇叙述性综述探讨了泌乳素同调假说的证据,尤其关注人体研究的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The homeo-FIT-prolactin hypothesis: the role of prolactin in metabolic homeostasis - association or causality?

The homeo-fit-prolactin hypothesis proposes a causal metabolic role for prolactin with hypoprolactinemia and hyperprolactinemia leading to adverse metabolic alterations. However, prolactin within the normal range and up to four times the upper reference limit may be a consequence of metabolic adaption and have a positive metabolic role similar to increased insulin in pre-diabetes. As a consequence, drugs that would increase prolactin levels within this threshold may hold promising effects, particularly for patients with type 2 diabetes. A documented positive metabolic effect of prolactin just above the normal threshold would not just be of benefit to patients with diabetes but assist in the decision to treat mild hyperprolactinemia in other patient groups as well, e.g. drug-induced hyperprolactinemia or idiopathic hyperprolactinemia. Prolactin receptors are present in the pancreas, liver, and adipose tissue, and pre-clinical studies suggest a positive and causal effect of prolactin on the gluco-insulinemic profile and lipid metabolism. This narrative review examines the evidence for the homeo-fit-prolactin hypothesis with a particular focus on results from human studies.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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