{"title":"空气污染与角膜病的发病率：两者之间有联系吗？","authors":"Tristan Jurkiewicz, Anne-Sophie Marty","doi":"10.1080/09286586.2024.2399765","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Keratoconus is a progressive, asymmetrical corneal ectasia with multifactorial origin. Three identified risk factors for keratoconus include exposure to ultraviolet (UV) rays, eye rubbing, and atopy. Other factors like pollution would play a role in the physiopathology of keratoconus. In this study we investigate the effects of particles matter (PM) of 2.5 and 10 μm, but also nitrogen dioxide (NO<sub>2</sub>) and the correlation with the prevalence in the scientific literature.</p><p><strong>Method: </strong>A literature review was performed using four databases (PubMed, Research gate, Google scholar and International Journal of Keratoconus and Ectatic Corneal Diseases) according to strict selection criteria. Levels of fine particles and nitrogen dioxide were extracted from available World Health Organization (WHO) databases and correlated with prevalences from epidemiological studies.</p><p><strong>Results: </strong>The mean pollution rate in the selected studies was 26.88 ± 25.26 μg/m<sup>3</sup> for PM<sub>2.5</sub> , 58.23 ± 60.98 μg/m<sup>3</sup> for PM<sub>10</sub> and 24.79 ± 12.58 μg/m<sup>3</sup> for NO<sub>2</sub>. Pearson correlation tests revealed a significant positive correlation between prevalence of keratoconus with particles rate of PM<sub>2.5</sub> (<i>R</i> = 0.58; <i>p</i> < 0.001), PM<sub>10</sub> (<i>R</i> = 0.67; <i>p</i> < 0.001) and NO<sub>2</sub> (<i>R</i> = 0.64; <i>p</i> = 0.00016).</p><p><strong>Conclusion: </strong>Fine particles appear to be a risk factor for keratoconus. These pollutants may act indirectly by exacerbating known risk factors such as atopy and eye rubbing. Atmospheric pollution may also have a direct effect on the cornea, by disturbing the structure of the epithelium and increasing cell apoptosis.</p>","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.7000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Air Pollution and the Prevalence of Keratoconus: Is There a Connection?\",\"authors\":\"Tristan Jurkiewicz, Anne-Sophie Marty\",\"doi\":\"10.1080/09286586.2024.2399765\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Keratoconus is a progressive, asymmetrical corneal ectasia with multifactorial origin. Three identified risk factors for keratoconus include exposure to ultraviolet (UV) rays, eye rubbing, and atopy. Other factors like pollution would play a role in the physiopathology of keratoconus. In this study we investigate the effects of particles matter (PM) of 2.5 and 10 μm, but also nitrogen dioxide (NO<sub>2</sub>) and the correlation with the prevalence in the scientific literature.</p><p><strong>Method: </strong>A literature review was performed using four databases (PubMed, Research gate, Google scholar and International Journal of Keratoconus and Ectatic Corneal Diseases) according to strict selection criteria. Levels of fine particles and nitrogen dioxide were extracted from available World Health Organization (WHO) databases and correlated with prevalences from epidemiological studies.</p><p><strong>Results: </strong>The mean pollution rate in the selected studies was 26.88 ± 25.26 μg/m<sup>3</sup> for PM<sub>2.5</sub> , 58.23 ± 60.98 μg/m<sup>3</sup> for PM<sub>10</sub> and 24.79 ± 12.58 μg/m<sup>3</sup> for NO<sub>2</sub>. Pearson correlation tests revealed a significant positive correlation between prevalence of keratoconus with particles rate of PM<sub>2.5</sub> (<i>R</i> = 0.58; <i>p</i> < 0.001), PM<sub>10</sub> (<i>R</i> = 0.67; <i>p</i> < 0.001) and NO<sub>2</sub> (<i>R</i> = 0.64; <i>p</i> = 0.00016).</p><p><strong>Conclusion: </strong>Fine particles appear to be a risk factor for keratoconus. These pollutants may act indirectly by exacerbating known risk factors such as atopy and eye rubbing. Atmospheric pollution may also have a direct effect on the cornea, by disturbing the structure of the epithelium and increasing cell apoptosis.</p>\",\"PeriodicalId\":19607,\"journal\":{\"name\":\"Ophthalmic epidemiology\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic epidemiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09286586.2024.2399765\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09286586.2024.2399765","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Air Pollution and the Prevalence of Keratoconus: Is There a Connection?
Purpose: Keratoconus is a progressive, asymmetrical corneal ectasia with multifactorial origin. Three identified risk factors for keratoconus include exposure to ultraviolet (UV) rays, eye rubbing, and atopy. Other factors like pollution would play a role in the physiopathology of keratoconus. In this study we investigate the effects of particles matter (PM) of 2.5 and 10 μm, but also nitrogen dioxide (NO2) and the correlation with the prevalence in the scientific literature.
Method: A literature review was performed using four databases (PubMed, Research gate, Google scholar and International Journal of Keratoconus and Ectatic Corneal Diseases) according to strict selection criteria. Levels of fine particles and nitrogen dioxide were extracted from available World Health Organization (WHO) databases and correlated with prevalences from epidemiological studies.
Results: The mean pollution rate in the selected studies was 26.88 ± 25.26 μg/m3 for PM2.5 , 58.23 ± 60.98 μg/m3 for PM10 and 24.79 ± 12.58 μg/m3 for NO2. Pearson correlation tests revealed a significant positive correlation between prevalence of keratoconus with particles rate of PM2.5 (R = 0.58; p < 0.001), PM10 (R = 0.67; p < 0.001) and NO2 (R = 0.64; p = 0.00016).
Conclusion: Fine particles appear to be a risk factor for keratoconus. These pollutants may act indirectly by exacerbating known risk factors such as atopy and eye rubbing. Atmospheric pollution may also have a direct effect on the cornea, by disturbing the structure of the epithelium and increasing cell apoptosis.
期刊介绍：
Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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