原发性家族性脑部钙化的机制和治疗途径透视。

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2024-10-09 DOI:10.1016/j.neuron.2024.09.019

Christer Betsholtz

引用次数: 0

摘要

原发性家族性脑钙化是一种遗传性神经退行性疾病，其病因多种多样，这使得治疗的希望变得渺茫。然而，《神经元》（Neuron）1,2 上的两篇新论文通过确定大脑磷酸盐转运机制和恢复大脑磷酸盐平衡的有望靶点，提供了乐观的理由。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Insights into mechanisms and therapeutic avenues for primary familial brain calcification.

The diverse etiologies of the genetic neurodegenerative disorder known as primary familial brain calcification have dimmed hopes for curative therapies. However, two new papers in Neuron¹^,² provide a reason for optimism by identifying mechanisms involved in brain phosphate transport and a promising target for restoring phosphate balance in the brain.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.