慢性生理失调与抑郁症状的变化:将性别和种族作为易感因素进行测试

IF 3.2 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Stacey N Doan, Alexandra S Aringer, Jessica M Vicman, Thomas Fuller-Rowell
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引用次数: 0

摘要

抑郁症是一个日益严重的公共健康问题,一生中约有 5%的成年人会受到抑郁症的影响(世界卫生组织《抑郁症》,2021 年)。了解抑郁症的生物学相关因素对于促进治疗至关重要。尤其值得关注的是静态负荷,它是慢性生理失调的多系统指标(McEwen 和 Seeman,1999 年纽约科学院学报)。目前的纵向研究考察了异位负荷、抑郁症状之间的关联,以及性别和种族的调节作用。研究对象包括 150 名年轻人(平均年龄为 18.81 岁),他们在一年半后的第一阶段和第二阶段报告了自己的人口统计数据和抑郁症状。研究人员利用代谢、心血管和神经内分泌功能指标计算了静态负荷。结果发现,代谢负荷可预测抑郁症状的变化。此外,交互效应模型显示,代谢负荷与随访抑郁症状之间的关系受性别的进一步影响,因此男性的代谢负荷与抑郁症状之间的关系显著,尤其是对黑人男性的影响更为明显。黑人男性可能特别容易受到生物失调对心理健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic Physiological Dysregulation and Changes in Depressive Symptoms: Testing Sex and Race as Vulnerability Factors.

Depression is a growing public health concern that affects approximately 5% of adults in their lifetime (WHO in Depression, 2021). Understanding the biological correlates of depression is imperative for advancing treatment. Of particular interest is allostatic load, a multisystem indicator of chronic physiological dysregulation (McEwen and Seeman in, Ann N Y Acad Sci, 1999). The current longitudinal study examined the association between allostatic load, depressive symptoms, and the moderating roles of sex and race. Participants consisted of 150 young adults (Mage = 18.81) who reported their demographics and depressive symptoms at T1 and T2, a year and a half later. Allostatic load was computed using indicators of metabolic, cardiovascular, and neuroendocrine functioning. Allostatic load was found to predict changes in depressive symptoms. Moreover, interaction effects models revealed that the associations between allostatic load and depressive symptoms at follow-up were further influenced by sex, such that the relationship was significant for males, with pronounced effects for Black males in particular. Black males may be particularly vulnerable to the mental health consequences of biological dysregulation.

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来源期刊
Journal of Racial and Ethnic Health Disparities
Journal of Racial and Ethnic Health Disparities PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
7.30
自引率
5.10%
发文量
263
期刊介绍: Journal of Racial and Ethnic Health Disparities reports on the scholarly progress of work to understand, address, and ultimately eliminate health disparities based on race and ethnicity. Efforts to explore underlying causes of health disparities and to describe interventions that have been undertaken to address racial and ethnic health disparities are featured. Promising studies that are ongoing or studies that have longer term data are welcome, as are studies that serve as lessons for best practices in eliminating health disparities. Original research, systematic reviews, and commentaries presenting the state-of-the-art thinking on problems centered on health disparities will be considered for publication. We particularly encourage review articles that generate innovative and testable ideas, and constructive discussions and/or critiques of health disparities.Because the Journal of Racial and Ethnic Health Disparities receives a large number of submissions, about 30% of submissions to the Journal are sent out for full peer review.
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