Gol-e-Gohar 铁矿气载粉尘诱导人类肺部 A549 细胞中毒的潜力。

IF 1.5 4区 医学 Q4 ENVIRONMENTAL SCIENCES
Athena Rafieepour, Mansour R Azari, Iraj Alimohammadi, Ali Asghar Farshad
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引用次数: 0

摘要

铁矿开采过程中的空气微粒是对人体肺部造成不良影响的一个风险因素。在这项研究中,我们通过擦拭取样的方法收集了沉积在距地面约 1.5 米和距 Gol-e-Gohar 铁矿一个磨矿装置 6 米处的微粒。直径小于 5 微米的粉尘颗粒用电子筛分离。从过筛的铁矿石粉尘中制备等分试样,估计其浓度相当于在铁矿石研磨机中呼吸接触的浓度,分别为 1、5、10、50、100 和 250 微克/毫升,以表示在矿山工作一个月到工作年限(25 年)的等效吸入剂量。空气中的可吸入颗粒物浓度约为美国政府工业卫生学家会议公布的氧化铁阈限值(TLV®)的五倍。据估计,体外毒性范围相当于在矿场工作一个月至一个工作年限的累积剂量。对 A549 细胞的处理导致脱氢酶活性和细胞谷胱甘肽含量降低,活性氧(ROS)生成、线粒体膜通透性和细胞凋亡-坏死率增加。这项研究的结果表明,可吸入空气中的氧化铁颗粒的细胞剂量估计相当于 Gol-e-Gohar 矿工终生累积接触的剂量,可能会造成肺损伤。建议开展进一步研究,调查工作场所的实际污染物对工人健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The potential of Gol-e-Gohar iron ore mine airborne dust to induce toxicity in human lung A549 cells.

Airborne particulates in iron ore mining are a risk factor for adverse human lung effects. In this study, fine particulates deposited on surfaces of about 1.5 m above the ground and 6 meters from a milling unit of the Gol-e-Gohar iron ore mine were collected through wipe sampling. Dust particles less than 5 µm in diameter were separated with an electronic sieve. Aliquots were prepared from the sieved iron ore dust estimated to be equivalent to respiratory exposure in the iron ore mill in the concentrations of 1, 5, 10, 50, 100, and 250 µg/mL, which were intended to represent equivalent inhaled doses from working one month to a working life (25 years) in the mine. The airborne concentration of respirable particles was about five times the threshold limit value given (TLV®) for iron oxide published by the American Conference of Governmental Industrial Hygienists. The in vitro toxicity range was estimated to be equivalent to an accumulated dose associated with working from one month to a working life in the mine. Treatment of the A549 cells resulted in decreased dehydrogenase activity and cell glutathione content and increased reactive oxygen species (ROS) generation, mitochondrial membrane permeability, and cell apoptosis-necrosis rates. The results of this study revealed the possibility of lung damage at cell doses for respirable airborne iron oxide particles estimated to be equivalent to accumulated lifetime exposures among Gol-e-Gohar miners. Further studies are recommended to investigate the effect of actual contaminants in the workplace on the occurrence of health effects on workers.

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来源期刊
Journal of Occupational and Environmental Hygiene
Journal of Occupational and Environmental Hygiene 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
3.30
自引率
10.00%
发文量
81
审稿时长
12-24 weeks
期刊介绍: The Journal of Occupational and Environmental Hygiene ( JOEH ) is a joint publication of the American Industrial Hygiene Association (AIHA®) and ACGIH®. The JOEH is a peer-reviewed journal devoted to enhancing the knowledge and practice of occupational and environmental hygiene and safety by widely disseminating research articles and applied studies of the highest quality. The JOEH provides a written medium for the communication of ideas, methods, processes, and research in core and emerging areas of occupational and environmental hygiene. Core domains include, but are not limited to: exposure assessment, control strategies, ergonomics, and risk analysis. Emerging domains include, but are not limited to: sensor technology, emergency preparedness and response, changing workforce, and management and analysis of "big" data.
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