一名 15 岁男孩患冠状病毒病-2019 相关史蒂文斯-约翰逊综合征:病例报告和文献综述。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Na Li, Jian Li
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引用次数: 0

摘要

背景:史蒂文斯-约翰逊综合征(Stevens-Johnson syndrome,SJS)是一种危及生命的疾病,其特征是高烧和严重的皮肤黏膜病变,通常由药物或感染引发。在 2019 年冠状病毒病大流行期间,史蒂文斯-约翰逊综合征病例明显增加,但儿童病例报告相对较少。本文报告了一例因冠状病毒病2019年最新注册送彩金感染导致的史蒂文斯-约翰逊综合征儿科病例,并对最相关的文献进行了综述:一名来自中国的15岁汉族男孩因口腔溃疡、结膜充血和广泛的斑丘疹到医院就诊。他在 9 天前曾有发热史,2019 年冠状病毒病感染检测呈阳性。入院后,他的皮疹和粘膜病变加重,双手指尖出现水疱,眼部疼痛,畏光,生殖器粘膜出现糜烂和渗出。他被诊断为史蒂文斯-约翰逊综合征,并接受了甲基强的松龙、静脉注射免疫球蛋白以及皮肤和粘膜护理等治疗。患者的病情得到控制,大剂量静脉注射甲基强的松龙的剂量逐渐减少,随后转为口服强的松龙。他出院时没有留下后遗症:我们应该意识到,2019 年冠状病毒病感染与儿童史蒂文斯-约翰逊综合征的发生有关,并可能导致多种皮肤病表现。虽然史蒂文斯-约翰逊综合征是一种相对罕见的疾病,但鉴于其潜在的严重后果,尽早发现并采取适当的预防和治疗措施以减少并发症和提高患者的生活质量至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coronavirus-disease-2019-associated Stevens-Johnsons syndrome in a 15-year-old boy: a case report and review of the literature.

Background: Stevens-Johnson syndrome (SJS) is a life-threatening condition characterized by high fever and severe mucocutaneous lesions, often triggered by drugs or infection. During the coronavirus disease 2019 pandemic, there was a marked increase in Stevens-Johnson syndrome cases, but relatively few cases were reported in children. The present article reports a pediatric case of Stevens-Johnson syndrome due to coronavirus disease 2019 infection and provides a review of the most relevant literature.

Case presentation: A previously healthy 15-year-old Han Chinese boy from China presented to the hospital with oral ulcers, conjunctival hyperemia, and widespread maculopapular rash. He had a history of fever 9 days prior and tested positive for coronavirus disease 2019 infection. Upon admission, his rash and mucosal lesions worsened, with the development of blisters on the fingertips of both hands, ocular pain, photophobia, and erosive lesions on the genital mucosa with exudation. He was diagnosed with Stevens-Johnson syndrome and received treatment with methylprednisolone, intravenous immunoglobulin, and dermatological and mucosal care. The patient's condition was managed, and the dosage of high-dose intravenous methylprednisolone was tapered down, followed by a transition to oral prednisolone. He was discharged without sequelae.

Conclusion: We should be aware that coronavirus disease 2019 infection is associated with the development of Stevens-Johnson syndrome in children and may lead to a wide spectrum of dermatologic presentations. Although Stevens-Johnson syndrome is a relatively rare condition, given its potentially serious consequences, it is crucial to identify it as early as possible and to take appropriate preventive and therapeutic measures to reduce complications and improve the quality of life for patients.

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来源期刊
Journal of Medical Case Reports
Journal of Medical Case Reports Medicine-Medicine (all)
CiteScore
1.50
自引率
0.00%
发文量
436
期刊介绍: JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
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