以头孢唑肟-阿维巴坦为基础的治疗方案治疗耐碳青霉烯类肺炎克雷伯氏菌引起的神经外科手术后脑室炎时感染部位的药效学目标达成情况：一份病例报告。

IF 4.9 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Antimicrobial Agents Pub Date : 2024-10-09 DOI:10.1016/j.ijantimicag.2024.107356

Yinru Chen , Wanzhen Li , Xiaofen Liu , Yan Chen , Jing Zhang , Nanyang Li , Lei Yang

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引用次数: 0

摘要

一名患者因患耐碳青霉烯类肺炎克雷伯菌和霉菌而引发神经外科手术后脑室炎，最初使用头孢他啶/阿维菌素和伏立康唑治疗。肺炎克雷伯氏菌碳青霉烯酶突变导致治疗方法调整为头孢他啶/阿维菌素和多粘菌素B，最终治愈。药代动力学/药效学分析强调了头孢他啶/阿维菌素的脑穿透和细菌清除功效。

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查看原文本刊更多论文

Pharmacodynamic Target Attainment at Infection Site During Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Klebsiella pneumoniae with Ceftazidime–Avibactam–Based Regimens: a case report

A patient developed a post-neurosurgical ventriculitis with carbapenem-resistant Klebsiella pneumoniae and mold, initially treated with ceftazidime/avibactam and voriconazole. A Klebsiella pneumoniae carbapenemase mutation led to therapy adjustment to ceftazidime/avibactam and polymyxin B, achieving cure. Pharmacokinetic/pharmacodynamic analysis highlights effective ceftazidime/avibactam brain penetration and bacterial clearance efficacy.

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来源期刊

International Journal of Antimicrobial Agents 医学-传染病学

CiteScore

21.60

自引率

0.90%

发文量

176

审稿时长

36 days

期刊介绍： The International Journal of Antimicrobial Agents is a peer-reviewed publication offering comprehensive and current reference information on the physical, pharmacological, in vitro, and clinical properties of individual antimicrobial agents, covering antiviral, antiparasitic, antibacterial, and antifungal agents. The journal not only communicates new trends and developments through authoritative review articles but also addresses the critical issue of antimicrobial resistance, both in hospital and community settings. Published content includes solicited reviews by leading experts and high-quality original research papers in the specified fields.