聚类分析确定了哪些严重嗜酸性粒细胞哮喘患者对美泊利珠单抗产生了超强反应并获得缓解

IF 6.3 2区医学 Q1 ALLERGY

Clinical and Experimental Allergy Pub Date : 2024-10-10 DOI:10.1111/cea.14584

Danilo Di Bona, Massimo Bilancia, Claudia Crimi, Michelina Daddato, Alida Benfante, Maria Filomena Caiaffa, Cecilia Calabrese, Raffaele Campisi, Santi Nolasco, Giovanna Elisiana Carpagnano, Maria D'Amato, Corrado Pelaia, Girolamo Pelaia, Angelantonio Maglio, Nicola Scichilone, Giulia Scioscia, Giuseppe Spadaro, Massimo Triggiani, Isabella Carrieri, Giuseppe Valenti, Alessandro Vatrella, Luigi Macchia, Nunzio Crimi

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引用次数: 0

摘要

这项研究确定了严重嗜酸性粒细胞性哮喘患者的两个不同亚群，他们对美泊利珠单抗的反应各不相同。聚类分析显示，有哮喘家族史、皮肤点刺试验阳性和基线肺功能较高的患者治疗效果更好，这凸显了个性化治疗策略的价值。

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查看原文本刊更多论文

Cluster Analysis Identifies Patients With Severe Eosinophilic Asthma Who Achieve Super-Response and Remission With Mepolizumab.

This study identifies two distinct subgroups of patients with severe eosinophilic asthma who respond differently to mepolizumab. Cluster analysis reveals that patients with a family history of asthma, positive skin prick tests and higher baseline lung function have better treatment outcomes, highlighting the value of personalised treatment strategies.

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.