烧瓶中的新底盘：天然弧菌生物技术研究进展。

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2024-10-09 DOI:10.1016/j.biotechadv.2024.108464

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引用次数: 0

摘要

生物技术一直是建立在少数特征鲜明、工程技术完善的生物体基础之上的。近年来，生物工程工具箱中出现了一种新的生物，它的表现备受瞩目：纳氏弧菌。本综述介绍了将纳氏弧菌打造成生物技术平台的最新研究成果，其中使用了大型语言模型（LLM）和知识图谱来加快文献调查过程。科学家们在与 V. natriegens 的基本代谢特征、合成生物学工具的开发和特征描述、系统生物学分析和代谢建模、生物生产和代谢工程以及微生物生态学有关的研究方面取得了进展。这些子类别中的每一个都与未来 V. natriegens 在生物工程方面的应用有关。在这篇综述中，我们将介绍这些最新进展，并就它们可能对该领域产生的影响提供背景资料，同时强调使用这种生物体的好处和缺点。从最近的生物工程研究来看，V. natriegens 即将成为未来生物技术的平台菌。

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The new chassis in the flask: Advances in Vibrio natriegens biotechnology research

Biotechnology has been built on the foundation of a small handful of well characterized and well-engineered organisms. Recent years have seen a breakout performer gain attention as a new entrant into the bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts into making V. natriegens a biotechnology platform, using a large language model (LLM) and knowledge graph to expedite the literature survey process. Scientists have made advancements in research pertaining to the fundamental metabolic characteristics of V. natriegens, development and characterization of synthetic biology tools, systems biology analysis and metabolic modeling, bioproduction and metabolic engineering, and microbial ecology. Each of these subcategories has relevance to the future of V. natriegens for bioengineering applications. In this review, we cover these recent advancements and offer context for the impact they may have on the field, highlighting benefits and drawbacks of using this organism. From examining the recent bioengineering research, it appears that V. natriegens is on the precipice of becoming a platform bacterium for the future of biotechnology.

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.