新诊断骨髓瘤患者的肾功能:与肾功能损害和恢复相关的因素。

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Bruno Nogueira Cesar, Walter Moises Tobias Braga, Nelson Hamerschlak, Marcelino de Souza Durão Junior
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引用次数: 0

摘要

肾脏疾病是多发性骨髓瘤(MM)的常见并发症,也是导致死亡率增加的风险因素。在这项基于病历的回顾性队列研究中,我们分析了与多发性骨髓瘤相关的肾病患者在治疗第一年的肾功能情况。所有纳入研究的患者均在 2009 年 1 月至 2019 年 1 月期间连续在两家医院的门诊部住院,且符合 MM 的诊断标准,无论其求医原因如何。我们排除了在确诊MM之前患有肾病或正在透析的患者。我们通过多变量分析研究了与肾功能恢复相关的因素。我们对 167 名患者(中位年龄为 66 ± 11.49 岁)进行了评估。几乎一半的患者患有动脉高血压(76;45.5%)。大多数患者的国际分期系统(ISS)分级为 3 级(73 人;43.7%)或 2 级(60 人;35.9%)。74名患者(44%)的估计肾小球滤过率(eGFR)为1.0 g,并患有髓外浆细胞瘤。然而,只有基线肾功能(eGFR > 60 ml/min/1.73 m2)和造血干细胞移植与随访 12 个月时肾功能的恢复程度更高有关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kidney function in newly diagnosed myeloma patients: factors associated with kidney impairment and recovery.

Kidney disease is a common complication of multiple myeloma (MM) and a risk factor for increased morbimortality. In this retrospective cohort study based on medical records, we analyzed the kidney function of patients with renal disease related to MM during the first year of treatment. All patients included were consecutively admitted to the outpatient services of two hospitals between January 2009 and January 2019 and met the diagnostic criteria for MM regardless of the reason for seeking medical help. We excluded patients who had kidney disease or who were on dialysis before MM diagnosis. We investigated the factors associated with renal function recovery using multivariate analysis. We evaluated 167 patients (median age of 66 ± 11.49 years). Almost half of the patients had arterial hypertension (76; 45.5%). The majority had International Staging System (ISS) grades 3 (73; 43.7%) or 2 (60; 35.9%). Seventy-four (44%) patients had an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m² at the time of MM diagnosis. Fifty-two patients (31%) underwent hematopoietic stem cell transplantation (HSCT). After 12 months, 4 (2.3%) patients needed dialysis, and 18 (10.7%) died. The factors associated with an eGFR < 60 ml/min/1.73 m² were anemia, hyperuricemia, 24-hour proteinuria > 1.0 g, and extramedullary plasmacytoma. However, only baseline renal function (eGFR > 60 ml/min/1.73 m2) and HSCT were associated with greater recovery of renal function at 12 months of follow-up.

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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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