Vinayaka Yadav, Shantala Hegde, M Netravathi, Mariamma Philip, Lee Cranberg
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Comparative analyses between RRMS patients and HCs were carried out for neuropsychological assessments. Correlations among cognitive functions, anxiety, depression, and QOL in RRMS patients were examined.</p><p><strong>Results: </strong>RRMS patients showed significant deficits across various cognitive domains, including processing speed and verbal learning, compared to HCs ( P < 0.05). In addition, they reported higher levels of trait anxiety compared to HCs ( P < 0.01), along with moderate state anxiety and mild depression. A significant correlation among anxiety, depression, and QOL was observed in RRMS patients.</p><p><strong>Conclusions: </strong>This study highlights significant cognitive impairments and psychological distress experienced by RRMS individuals, underscoring the critical need for comprehensive care addressing both cognitive impairments and psychological distress to enhance QOL.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Cognitive and Psychological Functions in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional Study.\",\"authors\":\"Vinayaka Yadav, Shantala Hegde, M Netravathi, Mariamma Philip, Lee Cranberg\",\"doi\":\"10.4103/aian.aian_434_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>To compare the cognitive functions and trait anxiety in patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) to those of matched healthy controls (HCs). In addition, the study aims to investigate the correlations among cognitive functions, anxiety, depression, and quality of life (QOL) in this clinical population.</p><p><strong>Methods: </strong>The sample included RRMS patients ( n = 21) and an equal number of age-, education-, and sex-matched HCs. Participants were assessed on the Indian version of the Wechsler Adult Intelligence Scale-IV, auditory and visual learning and memory, and visual-spatial construction and memory. RRMS patients were also assessed for levels of anxiety, depression, and their QOL. Comparative analyses between RRMS patients and HCs were carried out for neuropsychological assessments. Correlations among cognitive functions, anxiety, depression, and QOL in RRMS patients were examined.</p><p><strong>Results: </strong>RRMS patients showed significant deficits across various cognitive domains, including processing speed and verbal learning, compared to HCs ( P < 0.05). 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引用次数: 0
摘要
背景与目的比较复发缓解型多发性硬化症（RRMS）患者与匹配健康对照组（HCs）患者的认知功能和特质焦虑。此外，该研究还旨在探讨该临床人群的认知功能、焦虑、抑郁和生活质量（QOL）之间的相关性：样本包括 RRMS 患者（n = 21）和同等数量的年龄、教育程度和性别匹配的 HCs。对参与者进行了韦氏成人智力量表-IV印度版、听觉和视觉学习与记忆、视觉空间结构与记忆的评估。此外，还对 RRMS 患者的焦虑、抑郁水平及其 QOL 进行了评估。对 RRMS 患者和 HCs 的神经心理评估进行了比较分析。研究了 RRMS 患者认知功能、焦虑、抑郁和 QOL 之间的相关性：结果：与普通人相比，RRMS 患者在处理速度和言语学习等多个认知领域都存在明显缺陷（P < 0.05）。此外，与普通人相比，他们的特质焦虑水平更高（P < 0.01），还伴有中度状态焦虑和轻度抑郁。在 RRMS 患者中观察到焦虑、抑郁和 QOL 之间存在明显的相关性：本研究强调了 RRMS 患者所经历的严重认知障碍和心理困扰，强调了全面治疗认知障碍和心理困扰以提高 QOL 的迫切需要。
Impact of Cognitive and Psychological Functions in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional Study.
Background and objectives: To compare the cognitive functions and trait anxiety in patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) to those of matched healthy controls (HCs). In addition, the study aims to investigate the correlations among cognitive functions, anxiety, depression, and quality of life (QOL) in this clinical population.
Methods: The sample included RRMS patients ( n = 21) and an equal number of age-, education-, and sex-matched HCs. Participants were assessed on the Indian version of the Wechsler Adult Intelligence Scale-IV, auditory and visual learning and memory, and visual-spatial construction and memory. RRMS patients were also assessed for levels of anxiety, depression, and their QOL. Comparative analyses between RRMS patients and HCs were carried out for neuropsychological assessments. Correlations among cognitive functions, anxiety, depression, and QOL in RRMS patients were examined.
Results: RRMS patients showed significant deficits across various cognitive domains, including processing speed and verbal learning, compared to HCs ( P < 0.05). In addition, they reported higher levels of trait anxiety compared to HCs ( P < 0.01), along with moderate state anxiety and mild depression. A significant correlation among anxiety, depression, and QOL was observed in RRMS patients.
Conclusions: This study highlights significant cognitive impairments and psychological distress experienced by RRMS individuals, underscoring the critical need for comprehensive care addressing both cognitive impairments and psychological distress to enhance QOL.
期刊介绍：
The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.
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