线粒体膜间隙中的钙信号传递。

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shanikumar Goyani, Shatakshi Shukla, Pooja Jadiya, Dhanendra Tomar
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引用次数: 0

摘要

线粒体膜间隙(IMS)是一个高度受保护的腔室,仅次于基质。它是协调线粒体活动与代谢物、蛋白质、脂质和离子交换等细胞过程的重要桥梁。这种调节影响着代谢活动和细胞平衡的信号通路。IMS 含有多种蛋白质,对启动细胞凋亡级联和通过控制呼吸链调节活性氧的产生至关重要。钙(Ca2+)是细胞内重要的次级信使,通过 IMS 进入线粒体基质,调节线粒体生物能、ATP 的产生,并调节细胞死亡途径。由于存在不同的 Ca2+ 传感器,如 MICU、溶质运载体(SLC)、离子交换体(LETM1/SCaMC)、S100A1、线粒体甘油-3-磷酸脱氢酶和 EFHD1,每个传感器都有独特的 Ca2+ 结合基团和空间定位,因此 IMS 成为 Ca2+ 进入的调节场所。本综述主要强调这些 IMS 定位的 Ca2+ 传感器在空间定位、机制和分子功能方面的作用。此外,我们还讨论了这些传感器如何促进各种人类健康状况和疾病的发展和发病机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Calcium signaling in mitochondrial intermembrane space.

The mitochondrial intermembrane space (IMS) is a highly protected compartment, second only to the matrix. It is a crucial bridge, coordinating mitochondrial activities with cellular processes such as metabolites, protein, lipid, and ion exchange. This regulation influences signaling pathways for metabolic activities and cellular homeostasis. The IMS harbors various proteins critical for initiating apoptotic cascades and regulating reactive oxygen species production by controlling the respiratory chain. Calcium (Ca2+), a key intracellular secondary messenger, enter the mitochondrial matrix via the IMS, regulating mitochondrial bioenergetics, ATP production, modulating cell death pathways. IMS acts as a regulatory site for Ca2+ entry due to the presence of different Ca2+ sensors such as MICUs, solute carriers (SLCs); ion exchangers (LETM1/SCaMCs); S100A1, mitochondrial glycerol-3-phosphate dehydrogenase, and EFHD1, each with unique Ca2+ binding motifs and spatial localizations. This review primarily emphasizes the role of these IMS-localized Ca2+ sensors concerning their spatial localization, mechanism, and molecular functions. Additionally, we discuss how these sensors contribute to the progression and pathogenesis of various human health conditions and diseases.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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