光驱动的氯阴离子转运体

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2024-10-10 DOI:10.1016/j.chempr.2024.09.012

Chenxin Ou , Jinze Lv , Aaron J. Lim , Qing-Hui Guo , Yuanning Feng

引用次数: 0

摘要

人工跨膜转运体的最新进展可能解决了天然离子通道的局限性，其中包括 Aprahamian 等人开发的一种光开关 Cl- 阴离子泵（发表于《科学》1），该泵利用腙单元进行活性转运，对抗浓度梯度。这种分子转运体利用光诱导的异构化来控制阴离子的抓取和释放，在药物发现和分子机械方面显示出巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A light-driven chloride anion transporter

Recent advances in artificial transmembrane transporters that may address the limitations of natural ion channels include a photoswitchable Cl⁻ anion pump developed by Aprahamian et al., reported in Science,¹ utilizing hydrazone units for active transport against the concentration gradient. This molecular transporter leverages light-induced isomerization to control anion grabbing and releasing, showing significant potential for drug discovery and molecular machinery.

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.