铜粉介导的炔烃系酮肟的串联氢化环化-氢化氰化反应，生成具有氰基特征的环状硝基化合物

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-10-09 DOI:10.1002/adsc.202401049

Wen-Jun Han, Fang-Long Yang, Zhiyuan Hu, Wenxia Chen, Shun Liu, Ke Guo, Xin-Yuan Yang, Bin Cheng

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引用次数: 0

摘要

以 TMSCN 作为市售氰化试剂，介绍了铜粉介导的炔烃系酮肟的串联氢化环化-氢氰化反应。这种方法为合成一系列结构重要的氰基取代环腈提供了另一种策略。根据炔基的取代基模式，氢氰化过程表现出明显的区域选择性。此外，合成的产物还能进行各种衍生反应。

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Copper Powder-Mediated Tandem Hydroamination Cyclization-Hydrocyanation of Alkyne-Tethered Ketoximes toward Cyano-Featured Cyclic Nitrones

The copper powder-mediated tandem hydroamination cyclization-hydrocyanation of alkyne-tethered ketoximes is described by using TMSCN as the commercially available cyanating reagent. This methodology provides an alternative strategy for the synthesis of a series of structurally important cyano-substituted cyclic nitrones. The hydrocyanation process exhibits distinct regioselectivity depending on the substituent pattern of the alkyne moiety. Moreover, the synthesized products were shown to be capable of undergoing various derivatization reactions.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.