痴呆症家族史与童年和中年的大脑健康:一项基于社区的前瞻性研究

IF 7.7 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Rowina F. Hussainali, Isabel K. Schuurmans, Jendé L. Zijlmans, Charlotte A. M. Cecil, Meike W. Vernooij, Annemarie I. Luik, Ryan L. Muetzel, M. Arfan Ikram, Frank J. Wolters
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引用次数: 0

摘要

我们的目的是确定痴呆症家族史与大脑结构测量以及儿童期和成年中期认知能力的关系。我们研究了基于人群的一代人中的 1,259 名父母(平均年龄:47.3 岁,范围 31.9-67.4)和他们的 866 名子女(脑核磁共振成像时的平均年龄 [范围]:9.9 岁 [8.8-11.9],认知时的平均年龄 [范围]:13.5 岁 [12.6-15.8]):他们的子女(脑磁共振成像时的平均年龄[范围]:9.9岁[8.8-11.9岁],认知能力方面的平均年龄:13.5岁[12.6-15.8岁])均来自基于人口的R世代研究。父母填写了一份有关家族史的调查问卷,父母和孩子都接受了认知评估和神经影像学检查。在所有参与者中,109 名父母(8.6%)有父母家族痴呆症病史,73 名儿童(8.4%)有祖父母痴呆症病史,这些患者被诊断为痴呆症的平均年龄为 75 岁(± 7.3)。我们没有观察到痴呆症家族史与父母或子女的认知能力有任何关联,只是与没有痴呆症家族史的父母相比,有痴呆症家族史的父母的普渡挂板能力更差(平均差异[95%CI]:-1.23 [-2.15; -0.31],测试范围:21-52)。在父母和子女中,神经影像测量结果并不因家族病史而有显著差异。结果与年龄、性别和 APOE 基因型无关。痴呆症家族史与成年中期较差的手部灵活性有关,但与儿童期和中期的任何其他认知能力或亚临床脑健康指标无关。这些研究结果表明,家族病史与痴呆症风险的关联主要是由于神经退行性病变而非神经发育过程造成的,并且可能首先表现为运动技能的降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Family history of dementia and brain health in childhood and middle age: a prospective community-based study

Family history of dementia and brain health in childhood and middle age: a prospective community-based study

We aimed to determine the association of family history of dementia with structural brain measures and cognitive performance in childhood and mid-life adulthood. We studied 1,259 parents (mean age: 47.3 years, range 31.9–67.4) and 866 of their children (mean age [range] at brain MRI: 9.9 years [8.8–11.9], and for cognition: 13.5 years [12.6–15.8]) of the population-based Generation R Study. Parents filled in a questionnaire on family history, and both parents and children underwent cognitive assessment and neuroimaging. Of all participants, 109 parents (8.6%) reported a parental family history of dementia and 73 children (8.4%) had a grandparental history of dementia with mean age of dementia diagnosis in those affected 75 years (± 7.3). We observed no associations of dementia family history with cognitive ability in either parents or their children, except for worse Purdue pegboard in parents with a parental history of dementia, compared to those without (mean difference [95%CI]: -1.23 [-2.15; -0.31], test range: 21–52). In parents and children, neuroimaging measures did not differ significantly by family history. Results did not depend on age, sex, and APOE genotype. Family history of dementia was associated with worse manual dexterity in mid-life adulthood, but not with any other measures of cognitive ability or subclinical brain health in childhood and mid-life. These findings suggest that the association of family history with dementia risk is due chiefly to neurodegenerative rather than neurodevelopmental processes, and might first present with reduced motor skills.

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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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