{"title":"对故意沾染环磷酰胺的椅子扶手进行净化的 6 种方案的有效性。","authors":"Mathilde Dupré, Manon Marc, Jean-François Bussières","doi":"10.4212/cjhp.3588","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.</p><p><strong>Objective: </strong>To evaluate the effectiveness of decontamination scenarios.</p><p><strong>Methods: </strong>This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm<sup>2</sup>).</p><p><strong>Results: </strong>Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (<i>n</i> = 18), 99.90% (SD 0.15%) after 2 cleanses (<i>n</i> = 18), and 99.95% (SD 0.06%) after 3 cleanses (<i>n</i> = 15).</p><p><strong>Conclusion: </strong>The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.</p>","PeriodicalId":94225,"journal":{"name":"The Canadian journal of hospital pharmacy","volume":"77 4","pages":"e3588"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426960/pdf/","citationCount":"0","resultStr":"{\"title\":\"Efficacité de 6 scénarios de décontamination de bras de fauteuils contaminés volontairement au cyclophosphamide.\",\"authors\":\"Mathilde Dupré, Manon Marc, Jean-François Bussières\",\"doi\":\"10.4212/cjhp.3588\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.</p><p><strong>Objective: </strong>To evaluate the effectiveness of decontamination scenarios.</p><p><strong>Methods: </strong>This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm<sup>2</sup>).</p><p><strong>Results: </strong>Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (<i>n</i> = 18), 99.90% (SD 0.15%) after 2 cleanses (<i>n</i> = 18), and 99.95% (SD 0.06%) after 3 cleanses (<i>n</i> = 15).</p><p><strong>Conclusion: </strong>The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.</p>\",\"PeriodicalId\":94225,\"journal\":{\"name\":\"The Canadian journal of hospital pharmacy\",\"volume\":\"77 4\",\"pages\":\"e3588\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426960/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Canadian journal of hospital pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4212/cjhp.3588\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Canadian journal of hospital pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4212/cjhp.3588","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Efficacité de 6 scénarios de décontamination de bras de fauteuils contaminés volontairement au cyclophosphamide.
Background: The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.
Objective: To evaluate the effectiveness of decontamination scenarios.
Methods: This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm2).
Results: Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (n = 18), 99.90% (SD 0.15%) after 2 cleanses (n = 18), and 99.95% (SD 0.06%) after 3 cleanses (n = 15).
Conclusion: The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.
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