早发结直肠癌的可改变和不可改变风险因素：全国健康访谈调查分析。

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2024-10-08 DOI:10.1016/j.canep.2024.102682

Yahan Zhang, Ange Lu, Hyeun Ah Kang

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引用次数: 0

摘要

背景和目的：尽管在50岁以下的人群中确诊的结直肠癌（CRC），即早发性结直肠癌（EO-CRC）的发病率正在迅速上升，但EO-CRC的风险因素仍在不断确定之中。本研究旨在确认作为 EO-CRC 危险因素的可改变和不可改变特征：这项横断面研究使用了 2004-2018 年全国健康访谈调查（NHIS）数据，该数据提供了从全国年度家庭访谈调查中收集的全面健康信息。将 EO-CRC 患者的人口、临床和行为特征与非 EO-CRC 患者进行了比较。此外，还将他们与年龄无关的特征（性别、种族/民族、地区、体重指数[BMI]、饮酒量和吸烟状况）与平均发病型 CRC（AO-CRC）患者进行了比较。两种比较均进行了多变量逻辑回归分析：结果：我们发现了 156 例 EO-CRC 患者、204846 例非 CRC 患者和 1972 例 AO-CRC 患者。EO-CRC 组和非 EO-CRC 组之间的比较显示，年龄越大，患 EO-CRC 的几率越高（Odds Ratio [OR]=1.11, 95 % CI=1.08-1.14, pConclusion）：这项研究验证了几个可改变（即饮酒和体育锻炼）和不可改变（即种族/民族）的风险因素，同时还发现了一个与 EO-CRC 相关的新因素（即地理区域）。

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Modifiable and non-modifiable risk factors of early-onset colorectal cancer: National Health Interview Survey analysis

Background and aims

Although the incidence of colorectal cancer (CRC) diagnosed in individuals younger than 50 years, early-onset CRC (EO-CRC), is rapidly increasing, the risk factors for EO-CRC are still being identified. This study aimed to confirm the modifiable and non-modifiable characteristics identified as risk factors for EO-CRC.

Methods

This cross-sectional study used 2004–2018 National Health Interview Survey (NHIS) data, which provides comprehensive health information gathered from national annual household interview surveys. Demographic, clinical, and behavioral characteristics of EO-CRC patients were compared with those without. In addition, their non-age-related characteristics (gender, race/ethnicity, region, body mass index [BMI], alcohol consumption, and smoking status) were compared with individuals with average-onset CRC (AO-CRC). For both comparisons, multivariable logistic regression analyses were performed.

Results

We identified 156 patients with EO-CRC, 204,846 with non-CRC, and 1972 with AO-CRC. Comparison between the EO-CRC and the non-CRC groups showed that higher odds of having EO-CRC was associated with older age (Odds Ratio [OR]=1.11, 95 % CI=1.08–1.14, p<0.001), living in the Midwest (vs. South) (OR=1.64, 95 % CI=1.06–2.55, p=0.03), and history of alcohol consumption (vs. lifetime abstainer) (OR=2.09, 95 % CI=1.01–4.36, p=0.049). Lower odds of having EO-CRC were associated with being Hispanic (OR=0.43, 95 % CI=0.22–0.84, p=0.01) or Asian (OR=0.38, 95 % CI=0.16–0.92, p=0.03) (vs. non-Hispanic White) and having moderate or vigorous physical activities (vs. no activity) (OR=0.58, 95 % CI=0.34–0.999, p=0.0496 and OR=0.34; 95 % CI=0.21–0.55, p<0.0001, respectively). Compared with patients with AO-CRC, patients with EO-CRC were more likely to be Hispanic (vs. non-Hispanic White) (OR=2.21, 95 % CI=1.13–4.33, p=0.02).

Conclusion

This study verified several modifiable (i.e., alcohol consumption and physical activity) and non-modifiable (i.e., race/ethnicity) risk factors while also discovering a new factor (i.e., geographical region) associated with EO-CRC.

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.