表皮生长因子受体（EGFR）、RB1 和 MAP3K1 共同变异的 IA 期原发性肺腺癌的孤立肾转移：病例报告。

IF 1.9 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2024-10-09 DOI:10.1111/crj.70018

Zhu Qin, Chen Xin, He Zhenzhen, Xie Liang, Yi Wei, Li Shuben

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引用次数: 0

摘要

我们报告了一例59岁女性患者，她在IA期原发性肺腺癌术后出现单发双侧肾转移，并对两个病灶进行了新一代测序（NGS）。患者接受了右上叶切除术和淋巴结清扫术，术后发现原发性浸润性肺腺癌（pT1cN0M0，IA3 期）。此后两年，正电子发射计算机断层扫描（PET/CT）发现双肾多发肿块，无其他远处转移，超声引导下穿刺活检显示存在转移性肺腺癌。对原发病灶和转移病灶进行的 NGS 检测发现，表皮生长因子受体（EGFR）、RB 转录核心抑制因子 1（RB1）和丝裂原活化蛋白激酶激酶 1（MAP3K1）发生了共同改变，这可能与非小细胞肺癌术后早期肾转移的风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Solitary Renal Metastases From Stage IA Primary Lung Adenocarcinoma With Co-Alteration of EGFR, RB1, and MAP3K1: A Case Report

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Solitary Renal Metastases From Stage IA Primary Lung Adenocarcinoma With Co-Alteration of EGFR, RB1, and MAP3K1: A Case Report

We report a case of 59-year-old female with solitary bilateral renal metastases after surgery of stage IA primary lung adenocarcinoma who underwent next-generation sequencing (NGS) of both lesions. The patient received right upper lobectomy and lymph node dissection, which revealed primary invasive lung adenocarcinoma (pT1cN0M0, stage IA3). Two years following this, positron emission tomography–computed tomography (PET/CT) revealed multiple masses in both kidneys without other distant metastases, and ultrasonography-guided puncture biopsy indicated the presence of metastatic lung adenocarcinoma. The NGS of both the primary and metastatic lesions revealed the co-alteration of epidermal growth factor receptor (EGFR), RB transcriptional corepressor 1 (RB1), and mitogen-activated protein kinase kinase 1 (MAP3K1), which is potentially associated with the risk of renal metastasis in early postoperative non-small cell lung cancer.

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)