用于诊断卡拉-扎疹后皮肤利什曼病的快速抗原检测试验：CL Detect™ 快速检测试验在流行区活动病例检测中的应用。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-04-15 DOI:10.1093/infdis/jiae497

Mudsser Azam, Vidya Nand R Das, V Ramesh, Tathagata Gupta, Roshan Kamal Topno, Keerti Kaumudee Dixit, Poonam Salotra, Ruchi Singh

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引用次数: 0

摘要

卡拉扎病后皮肤利什曼病（PKDL）是一种皮肤病，一小部分内脏利什曼病（VL）患者在治愈后会出现这种皮肤病，并导致VL的传播。rK39快速检测仪不能对PKDL做出决定性诊断，因为它检测出了过去VL发作时产生的抗利什曼病抗体。CL Detect™ 快速检测法是一种体外诊断检测法，可检测利什曼病抗原过氧化物酶，被用于诊断 PKDL。在这项研究中，CL Detect RDT 的灵敏度为 73.3%，特异性为 100%。该检测可作为一种初级筛查工具，在利什曼病流行地区监测利什曼病，并确定利什曼病的活动感染。

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Rapid Antigen Detection Test for Diagnosis of Post-kala-azar Dermal Leishmaniasis: Application of CL Detect Rapid Test for Active Case Detection in the Endemic Area.

Post-kala-azar dermal leishmaniasis (PKDL) is a skin condition that occurs in a small percentage of people who have been cured of visceral leishmaniasis (VL), and it contributes to transmission of VL. The rK39 rapid test cannot decisively diagnose PKDL due to the presence of antileishmanial antibodies from past VL episodes. The CL Detect Rapid Test, an in vitro diagnostic test that detects Leishmania antigen peroxidoxin, was assessed for diagnosing PKDL. The CL Detect Rapid Test had 73.3% sensitivity and 100% specificity in the study. The test can be used as a primary screening tool to monitor PKDL in endemic regions and identify active Leishmania infection.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.