专题讨论会：微生物组对预防和治疗注意力缺失症/注意力缺失性痴呆症有何启示？

IF 4.4 2区医学 Q1 NEUROSCIENCES

Journal of Neuroscience Pub Date : 2024-10-09 DOI:10.1523/JNEUROSCI.1295-24.2024

Joia K Capocchi, Claudia Figueroa-Romero, Sage J B Dunham, Gina Faraci, Jason A Rothman, Katrine L Whiteson, Dong-Oh Seo, David M Holtzman, Stefanie Grabrucker, Yvonne M Nolan, Rima Kaddurah-Daouk, David A Jett

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引用次数: 0

摘要

阿尔茨海默病（AD）和阿尔茨海默病相关痴呆（ADRDs）是影响广泛的多因素神经退行性疾病。它们的复杂性给开发有效疗法带来了独特的挑战。本综述重点介绍了在 2024 年神经科学学会会议上发表的研究，这些研究强调了肠道微生物组通过微生物群-肠-脑轴影响大脑功能和神经退行性病变，从而在痴呆症发病机制中发挥作用。这些新出现的证据强调了以肠道微生物群为靶点治疗注意力缺失症/注意力缺失性障碍的潜力。

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Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

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来源期刊

Journal of Neuroscience 医学-神经科学

CiteScore

9.30

自引率

3.80%

发文量

1164

审稿时长

12 months

期刊介绍： JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles