从 T1 加权磁共振成像获取的定量脑 T1 图:概念验证研究。

IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Audrey Lavielle, Noël Pinaud, Bei Zhang, Yannick Crémillieux
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引用次数: 0

摘要

背景:纵向 T1 松弛时间是一种关键的成像生物标志物。此外,肿瘤和转移瘤患者使用的 T1 造影剂会调节 T1 值。然而,在临床实践中,脑部磁共振成像方案往往不包括专用的 T1 映射序列。本研究旨在通过标准 T1 加权序列得出 T1 图谱,解决成像方案中缺乏专用 T1 图谱序列的问题:方法:使用专为脑成像设计的三维(3D)T1 加权涡轮自旋回波(TSE)序列对一个由 144 种不同浓度的顺磁剂溶液组成的模型进行成像。利用该模型采集建立了 T1 值与信号强度之间的关系。对四名健康志愿者和一名脑转移患者进行了三维 T1 加权 TSE 采集,建立了 T1 映射,并与参考 T1 映射技术进行了比较。根据得出的 T1 图谱评估了脑转移瘤中钆基造影剂的浓度:结果:根据模型采集,发现 T1 值与信号强度(SI)之间的关系等于 T1 = 0.35 × SI-1.11(R2 = 0.97)。健康志愿者白质和灰质的 TSE 导出 T1 值分别为 0.997 ± 0.096 秒和 1.358 ± 0.056 秒(平均值 ± 标准差)。脑转移瘤中 Gd3+ 浓度的平均值为 94.7 ± 30.0 μM:体内结果支持基于模型的方法的相关性:脑T1图可以从T1加权采集中得出:利用常规三维T1加权TSE采集可生成高分辨率脑T1图,并对脑转移灶的造影剂浓度进行量化和成像:要点:定量 T1 映像为核磁共振成像诊断增添了重要价值。T1测量序列很少被纳入常规方案。T1图谱和造影剂浓度可从常规标准扫描中得出。无需增加扫描时间即可提高磁共振成像的诊断价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quantitative brain T1 maps derived from T1-weighted MRI acquisitions: a proof-of-concept study.

Background: Longitudinal T1 relaxation time is a key imaging biomarker. In addition, T1 values are modulated by the administration of T1 contrast agents used in patients with tumors and metastases. However, in clinical practice, dedicated T1 mapping sequences are often not included in brain MRI protocols. The aim of this study is to address the absence of dedicated T1 mapping sequences in imaging protocol by deriving T1 maps from standard T1-weighted sequences.

Methods: A phantom, composed of 144 solutions of paramagnetic agents at different concentrations, was imaged with a three-dimensional (3D) T1-weighed turbo spin-echo (TSE) sequence designed for brain imaging. The relationship between the T1 values and the signal intensities was established using this phantom acquisition. T1 mapping derived from 3D T1-weighted TSE acquisitions in four healthy volunteers and one patient with brain metastases were established and compared to reference T1 mapping technique. The concentration of Gd-based contrast agents in brain metastases were assessed from the derived T1 maps.

Results: Based on the phantom acquisition, the relationship between T1 values and signal intensity (SI) was found equal to T1 = 0.35 × SI-1.11 (R2 = 0.97). TSE-derived T1 values measured in white matter and gray matter in healthy volunteers were equal to 0.997 ± 0.096 s and 1.358 ± 0.056 s (mean ± standard deviation), respectively. Mean Gd3+ concentration value in brain metastases was 94.7 ± 30.0 μM.

Conclusion: The in vivo results support the relevance of the phantom-based approach: brain T1 maps can be derived from T1-weighted acquisitions.

Relevance statement: High-resolution brain T1 maps can be generated, and contrast agent concentration can be quantified and imaged in brain metastases using routine 3D T1-weighted TSE acquisitions.

Key points: Quantitative T1 mapping adds significant value to MRI diagnostics. T1 measurement sequences are rarely included in routine protocols. T1 mapping and concentration of contrast agents can be derived from routine standard scans. The diagnostic value of MRI can be improved without additional scan time.

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来源期刊
European Radiology Experimental
European Radiology Experimental Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.70
自引率
2.60%
发文量
56
审稿时长
18 weeks
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