{"title":"子宫输卵管造影术中乙碘和 Ioversol 造影剂的图像质量和安全性比较:元分析。","authors":"Yun Tian, Zhenglong Chen, Peng Chen, Faling Song","doi":"10.1620/tjem.2024.J106","DOIUrl":null,"url":null,"abstract":"<p><p>The selection of an hysterosalpingography (HSG) contrast medium is quite essential due to the different imaging performances and safety profiles among contrast medium during the HSG procedure. Ethiodol and ioversol are the most common contrast mediums, whose superiority of imaging performance and safety profile during HSG is controversial. This meta-analysis aimed to comprehensively compare image quality and safety between infertility patients who received HSG with ethiodol and ioversol. PubMed, Web of Science (WOS), Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang, and Chongqing VIP (CQVIP) were utilized for literature searching until September 1, 2023. Twelve cohort studies containing 3,622 patients who underwent HSG with ioversol (N = 1,693) or ethiodol (N = 1,929) were included. Ethiodol realized an elevated rate of good and excellent image quality compared to ioversol (risk ratio (RR) = 0.94, 95% confidence intervals (CI): 0.89-1.00, P = 0.035). Whereas the incidence of overall adverse events (AEs) was reduced in patients receiving HSG with ioversol than ethiodol (RR = 0.53, 95% CI: 0.32-0.86, P = 0.011). Nevertheless, incidences of each adverse event, including reflux of contrast medium, abdominal pain, nausea and vomiting, and cough, were not different between patients receiving HSG with ioversol and ethiodol (all P > 0.050). The risk of bias was low, and there was no evidence of publication bias. Meanwhile, sensitivity analysis revealed that the result of image quality was affected by omitting some studies, but most other results were robust. Conclusively, ethiodol realizes improved image quality but ioversol realizes fewer overall AEs for HSG in infertility patients, suggesting that their clinical selection can refer to actual demands.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Image Quality and Safety Profile between Ethiodol and Ioversol Contrast Medium for Hysterosalpingography: A Meta-Analysis.\",\"authors\":\"Yun Tian, Zhenglong Chen, Peng Chen, Faling Song\",\"doi\":\"10.1620/tjem.2024.J106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The selection of an hysterosalpingography (HSG) contrast medium is quite essential due to the different imaging performances and safety profiles among contrast medium during the HSG procedure. Ethiodol and ioversol are the most common contrast mediums, whose superiority of imaging performance and safety profile during HSG is controversial. This meta-analysis aimed to comprehensively compare image quality and safety between infertility patients who received HSG with ethiodol and ioversol. PubMed, Web of Science (WOS), Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang, and Chongqing VIP (CQVIP) were utilized for literature searching until September 1, 2023. Twelve cohort studies containing 3,622 patients who underwent HSG with ioversol (N = 1,693) or ethiodol (N = 1,929) were included. Ethiodol realized an elevated rate of good and excellent image quality compared to ioversol (risk ratio (RR) = 0.94, 95% confidence intervals (CI): 0.89-1.00, P = 0.035). Whereas the incidence of overall adverse events (AEs) was reduced in patients receiving HSG with ioversol than ethiodol (RR = 0.53, 95% CI: 0.32-0.86, P = 0.011). Nevertheless, incidences of each adverse event, including reflux of contrast medium, abdominal pain, nausea and vomiting, and cough, were not different between patients receiving HSG with ioversol and ethiodol (all P > 0.050). The risk of bias was low, and there was no evidence of publication bias. Meanwhile, sensitivity analysis revealed that the result of image quality was affected by omitting some studies, but most other results were robust. 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引用次数: 0
摘要
子宫输卵管造影(HSG)造影剂的选择是非常必要的,因为在HSG过程中不同的造影剂的成像性能和安全性是不同的。硫代酚和硫代酚是最常见的造影剂,其在HSG中的成像性能和安全性方面的优势存在争议。本荟萃分析旨在全面比较使用硫代酚和硫代酚接受HSG治疗的不孕症患者的图像质量和安全性。使用PubMed、Web of Science (WOS)、谷歌Scholar、CNKI、万方、重庆VIP (CQVIP)进行文献检索,检索截止日期为2023年9月1日。纳入了12项队列研究,共包含3,622例使用ioversol (N = 1,693)或ethiodool (N = 1,929)接受HSG治疗的患者。与ioversol相比,Ethiodol的图像质量良、优率更高(风险比(RR) = 0.94, 95%可信区间(CI): 0.89-1.00, P = 0.035)。而在接受HSG治疗的患者中,ioversol的总不良事件(ae)发生率低于ethiodool (RR = 0.53, 95% CI: 0.32-0.86, P = 0.011)。然而,每一项不良事件的发生率,包括造影剂反流、腹痛、恶心呕吐和咳嗽,在接受HSG治疗的患者中使用ioversol和ethiodool并无差异(P均为0.050)。偏倚风险低,无发表偏倚证据。同时,灵敏度分析显示,忽略部分研究会影响图像质量的结果,但大多数结果是稳健的。综上所述,对于不孕症患者的HSG,硫代酚能提高图像质量,而碘代酚能降低总体ae,提示临床选择可根据实际需要。
Comparison of Image Quality and Safety Profile between Ethiodol and Ioversol Contrast Medium for Hysterosalpingography: A Meta-Analysis.
The selection of an hysterosalpingography (HSG) contrast medium is quite essential due to the different imaging performances and safety profiles among contrast medium during the HSG procedure. Ethiodol and ioversol are the most common contrast mediums, whose superiority of imaging performance and safety profile during HSG is controversial. This meta-analysis aimed to comprehensively compare image quality and safety between infertility patients who received HSG with ethiodol and ioversol. PubMed, Web of Science (WOS), Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang, and Chongqing VIP (CQVIP) were utilized for literature searching until September 1, 2023. Twelve cohort studies containing 3,622 patients who underwent HSG with ioversol (N = 1,693) or ethiodol (N = 1,929) were included. Ethiodol realized an elevated rate of good and excellent image quality compared to ioversol (risk ratio (RR) = 0.94, 95% confidence intervals (CI): 0.89-1.00, P = 0.035). Whereas the incidence of overall adverse events (AEs) was reduced in patients receiving HSG with ioversol than ethiodol (RR = 0.53, 95% CI: 0.32-0.86, P = 0.011). Nevertheless, incidences of each adverse event, including reflux of contrast medium, abdominal pain, nausea and vomiting, and cough, were not different between patients receiving HSG with ioversol and ethiodol (all P > 0.050). The risk of bias was low, and there was no evidence of publication bias. Meanwhile, sensitivity analysis revealed that the result of image quality was affected by omitting some studies, but most other results were robust. Conclusively, ethiodol realizes improved image quality but ioversol realizes fewer overall AEs for HSG in infertility patients, suggesting that their clinical selection can refer to actual demands.
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