无论是原发性抗磷脂综合征还是伴发于系统性红斑狼疮的抗磷脂综合征,与健康相关的生活质量损害都是相同的。

IF 1.4 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2024-01-01 Epub Date: 2024-09-16 DOI:10.5114/reum/192028
Ewa Haladyj, Agata Matusiewicz, Tomasz Wysocki, Marzena Olesinska
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引用次数: 0

摘要

简介抗磷脂综合征(APS)表现为血栓形成和妊娠失败,可能会严重影响与健康相关的生活质量(HRQoL)。迄今为止,APS 被认为是一种比系统性红斑狼疮(SLE)负担更轻的疾病,但这方面的数据却很少。本研究的目的是通过应用简表36健康调查(SF-36)和世界卫生组织生活质量量表(WHOQoL-BREF)评估APS患者的HRQoL;研究原发性APS和并存系统性红斑狼疮(APS/SLE)对患者HRQoL的影响;并对APS患者群体进行描述:研究纳入了 112 名 APS 患者,其中 57 人患有原发性 APS,55 人同时患有系统性红斑狼疮。HRQoL通过36项SF-36和WHOQoL问卷进行测量:平均年龄为 47 岁(47.6 ±13.8),96 名患者为女性(85.7%)。平均病程为 72 个月。与波兰健康人群相比,所有 APS 患者的健康相关生活质量都受到了损害(P < 0.0001)。APS组和APS/SLE组在健康相关生活质量方面没有差异(精神部分p = 1.0,身体部分p = 0.337)。静脉血栓病史仅在 APS/SLE 组的身体部分与 HRQoL 损害相关(p = 0.0118),而在原发性 APS 组则与 HRQoL 损害无关(p = 0.6862)。SF-36的精神部分与WHOQoL-BREF的所有领域相关,而身体部分仅与身体健康相关(p < 0.001):结论:原发性APS和继发于系统性红斑狼疮的APS会导致相同的HRQoL损害。对所有 APS 患者进行诊断和适当管理对于预防血栓形成和流产至关重要,这将最终延长患者的生存期并提高其生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Health-related quality of life impairment is equal for antiphospholipid syndrome whether primary or associated with systemic lupus erythematosus.

Introduction: Antiphospholipid syndrome (APS) manifests with thrombosis and pregnancy losses and may significantly impair the health-related quality of life (HRQoL). So far, APS has been perceived as a less burdensome disease than systemic lupus erythematosus (SLE), but data on this are scarce. The purpose of the present study was to evaluate HRQoL in APS patients by applying the Short Form 36 Health Survey (SF-36) and World Health Organization Quality-of-Life Scale (WHOQoL-BREF); to examine the impact of primary APS and with coexisting SLE (APS/SLE) on patient HRQoL; and to provide a description of the APS patient population.

Material and methods: One hundred twelve patients with APS were included in the study, 57 of them with primary APS and 55 with coexisting SLE. HRQoL was measured by the 36-Item SF-36 and WHOQoL questionnaires.

Results: Mean age was 47 years (47.6 ±13.8), and 96 patients were (85.7%) women. The mean disease duration was 72 months. Health-related quality of life impairment was found in both components for all APS patients in comparison to the healthy Polish population (p < 0.0001). There was no difference between APS and APS/SLE groups in HRQoL (mental component p = 1.0, physical component p = 0.337). The history of venous thrombosis was associated with HRQoL impairment only in the APS/SLE group in the physical component (p = 0.0118), not in primary APS (p = 0.6862). The mental component of SF-36 was associated with all domains of WHOQoL-BREF, while the physical component was associated only with physical health (p < 0.001).

Conclusions: Primary APS and APS secondary to SLE lead to equal impairment in HRQoL. Diagnosis and proper management of all patients with APS are essential to prevent thrombosis and miscarriages, which ultimately will lead to longer survival with optimal life quality.

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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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