非临床人群中的颞上沟折叠、功能网络连接和自闭症样特征。

IF 6.3 1区 医学 Q1 GENETICS & HEREDITY
Igor Nenadić, Yvonne Schröder, Jonas Hoffmann, Ulrika Evermann, Julia-Katharina Pfarr, Aliénor Bergmann, Daniela Michelle Hohmann, Boris Keil, Ahmad Abu-Akel, Sanna Stroth, Inge Kamp-Becker, Andreas Jansen, Sarah Grezellschak, Tina Meller
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引用次数: 0

摘要

背景:自闭症样特征(ALT)在普通人群中普遍存在,可能与更广泛的自闭症谱系障碍(ASD)表型的某些方面有关。最近的研究表明,这些特征与非自闭症患者的遗传和大脑结构标志物都有关联,显示了在自闭症谱系障碍中观察到的类似发现的空间位置,从而提示了潜在的神经生物学连续性:在这项研究中,我们首先测试了 ALTs(通过 AQ 问卷进行评估)与皮质复杂性(早期神经发育的皮质表面标志)之间的关联,然后测试了其与功能连接紊乱之间的关联。我们对 250 名无早期发育障碍史的精神健康人进行了结构性 T1 加权和静息态功能磁共振成像扫描分析,第一步使用 CAT12 工具箱进行皮层复杂性分析,第二步使用区域皮层复杂性结果应用 CONN 工具箱进行基于种子的功能连通性分析:结果:我们的研究结果表明,AQ总分和AQ注意转换分值与左侧颞上沟(STS)皮层折叠复杂性呈显著负相关,前者与STS与左侧枕叶外侧皮层的连通性显著相关,而后者与STS与左侧额叶下回/中回的连通性呈显著正相关(n = 233;所有P 限制:表型可能会影响关联结果(如清单的选择);此外,我们的研究仅限于自闭症样特征的亚临床表现:我们的研究结果为ALT的生物学相关性提供了进一步的证据,即使没有临床自闭症,同时也在早期发育起源的结构变异与功能连接之间建立了联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population.

Background: Autistic-like traits (ALT) are prevalent across the general population and might be linked to some facets of a broader autism spectrum disorder (ASD) phenotype. Recent studies suggest an association of these traits with both genetic and brain structural markers in non-autistic individuals, showing similar spatial location of findings observed in ASD and thus suggesting a potential neurobiological continuum.

Methods: In this study, we first tested an association of ALTs (assessed with the AQ questionnaire) with cortical complexity, a cortical surface marker of early neurodevelopment, and then the association with disrupted functional connectivity. We analysed structural T1-weighted and resting-state functional MRI scans in 250 psychiatrically healthy individuals without a history of early developmental disorders, in a first step using the CAT12 toolbox for cortical complexity analysis and in a second step we used regional cortical complexity findings to apply the CONN toolbox for seed-based functional connectivity analysis.

Results: Our findings show a significant negative correlation of both AQ total and AQ attention switching subscores with left superior temporal sulcus (STS) cortical folding complexity, with the former being significantly correlated with STS to left lateral occipital cortex connectivity, while the latter showed significant positive correlation of STS to left inferior/middle frontal gyrus connectivity (n = 233; all p < 0.05, FWE cluster-level corrected). Additional analyses also revealed a significant correlation of AQ attention to detail subscores with STS to left lateral occipital cortex connectivity.

Limitations: Phenotyping might affect association results (e.g. choice of inventories); in addition, our study was limited to subclinical expressions of autistic-like traits.

Conclusions: Our findings provide further evidence for biological correlates of ALT even in the absence of clinical ASD, while establishing a link between structural variation of early developmental origin and functional connectivity.

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来源期刊
Molecular Autism
Molecular Autism GENETICS & HEREDITY-NEUROSCIENCES
CiteScore
12.10
自引率
1.60%
发文量
44
审稿时长
17 weeks
期刊介绍: Molecular Autism is a peer-reviewed, open access journal that publishes high-quality basic, translational and clinical research that has relevance to the etiology, pathobiology, or treatment of autism and related neurodevelopmental conditions. Research that includes integration across levels is encouraged. Molecular Autism publishes empirical studies, reviews, and brief communications.
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