Haichang Luo, McKinzie Frederick, Ezequiel Marron Fernandez de Velasco, Jenna Osterlund Oltmanns, Courtney Wright, Kevin Wickman
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引用次数: 0
摘要
G 蛋白门控内向整流 K+(GIRK)通道介导海马中许多神经递质的突触后抑制作用,并与以认知障碍为特征的神经系统疾病有关。在这里,我们发现增强或抑制背侧 CA1 锥体神经元中 GIRK 通道的活性会破坏小鼠对新物体的识别,但不会影响开阔场活动或回避行为。雄性小鼠的情境恐惧学习也不受影响,但情境恐惧的消退会因抑制 GIRK 通道活性而中断。因此,背侧CA1锥体神经元中GIRK通道活动的强度调节了小鼠选择性认知任务的表现。
Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus.
G protein-gated inwardly rectifying K+ (GIRK) channels mediate the postsynaptic inhibitory effect of many neurotransmitters in the hippocampus and are implicated in neurological disorders characterized by cognitive deficits. Here, we show that enhancement or suppression of GIRK channel activity in dorsal CA1 pyramidal neurons disrupted novel object recognition in mice, without impacting open field activity or avoidance behavior. Contextual fear learning was also unaffected, but extinction of contextual fear was disrupted by suppression of GIRK channel activity in male mice. Thus, the strength of GIRK channel activity in dorsal CA1 pyramidal neurons regulates select cognitive task performance in mice.
期刊介绍:
The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.