慢性睡眠不足会改变 C57BL/6J 小鼠的炎症反应和 BDNF 表达。

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-09-30 DOI:10.1016/j.jneuroim.2024.578462

Kelly N. Brice , Paige N. Braden-Kuhle , Shelby K. Miller , Allison Regan , Vivienne Lacy , Michael J. Chumley , Gary W. Boehm

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引用次数: 0

摘要

虽然充足的睡眠对正常的生理功能至关重要，但超过三分之一的美国成年人睡眠不足。目前的研究调查了雄性和雌性小鼠在受到免疫损伤后，慢性睡眠限制（CSR）对炎症标志物和海马BDNF mRNA的影响。雄性小鼠与雌性小鼠的细胞因子表达模式不同，这表明CSR后炎症反应可能存在性别差异。此外，CSR导致雄性小鼠海马BDNF的表达受到抑制，而雌性小鼠则没有观察到这种效应。这些数据表明，慢性睡眠不足、炎症和性别之间存在复杂的相互作用，值得进一步研究。

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Chronic sleep loss alters the inflammatory response and BDNF expression in C57BL/6J mice

Although adequate sleep is imperative for proper physiological function, over one-third of US adults obtain insufficient sleep. The current research investigated the impact of chronic sleep restriction (CSR) on inflammatory markers and hippocampal BDNF mRNA, following an immune insult in both male and female mice. Patterns of cytokine expression were different when the study was done in males vs. females, indicating potential sex differences in the inflammatory response following CSR. Further, CSR led to suppressed hippocampal BDNF expression in males, an effect not observed in females. These data suggest a complex interaction between chronic sleep loss, inflammation, and sex that warrants further exploration.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.