已不再受关注,但仍有意义?有基础疾病的 60 岁以下成年人的流感相关资源利用率和疫苗接种覆盖率差距:德国 2016-2024 年真实世界数据分析。

IF 2.9 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Medical Economics Pub Date : 2024-01-01 Epub Date: 2024-10-18 DOI:10.1080/13696998.2024.2413284
Laura Colombo, Julian Witte, Daniel Gensorowsky, Manuel Batram, Sanjay Hadigal
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引用次数: 0

摘要

背景:2003 年,世卫组织的目标是在高危人群中实现 75% 或更高的流感疫苗接种率。然而,在一些欧洲国家,只有少数群体在特定季节实现了这一目标,而德国从未实现过这一目标。患有基础疾病 (UC) 的成年人是流感疫苗接种的一个关键的被忽视群体。本研究旨在确定德国 60 岁以下患有基础疾病的成年人在流感负担和疫苗接种覆盖率方面的数据缺口,并利用真实世界的数据弥补这些缺口:我们利用 2016 年 6 月至 2024 年 4 月期间的德国行政和索赔数据库进行了系统研究和分析。我们报告了流行病学、直接护理成本、因丧失工作能力而产生的间接成本、疫苗接种覆盖率,并描述了数据缺口:结果:针对高危人群的流感数据非常有限。流感流行病学和疫苗接种覆盖率(VCR)方面的综合数据已经可用,但数据可用性有所延迟。在流感大流行前后,50-59 岁人群与流感相关的住院率和重症监护室入院率均高于年轻群体。在所有年龄组和季节中,患有 UC 的人的流感病例就诊率、住院率和医疗费用都较高,其中 35-59 岁的人尤其容易受到影响。35-59岁成年人的疫苗接种率高于18-24岁成年人,女性高于男性:局限性:疫苗接种情况存在差异,数据可用性有限,统一接种率存在差异:在德国,近期的政策措施主要针对 60 岁及以上的人群。虽然老年人群受到的疾病相关影响最大,但流感也会导致慢性 UCs 的年轻群体大量使用医疗资源 (HCRU) 并产生费用;通过药房等途径为这一群体提供疫苗接种便利至关重要。需要确定可量化的疫苗接种目标,并根据这些目标采取措施提高疫苗接种率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Out of focus but still relevant? Influenza-related resource utilization and vaccination coverage gaps in adults below 60 years of age with underlying conditions: an analysis of 2016-2024 real-world data in Germany.

Background: In 2003, the WHO aimed for a 75% or higher influenza vaccination rate among at-risk populations. However, this target was achieved in a few groups during selected seasons in some European countries, and never in Germany. Adults with underlying conditions (UCs) are a critical negleted group for influenza vaccination. This study aimed to identify data gaps in influenza burden and vaccination coverage among adults under 60 with UCs in Germany and bridge these gaps using real-world data.

Material and methods: We conducted systematic research and analyses using German administrative and claims databases from June 2016 to April 2024. We report on epidemiology, direct care costs, indirect costs from work incapacity, vaccination coverage rates, and describe data gaps.

Results: Influenza data for high-risk populations are limited. Comprehensive data on influenza epidemiology and vaccination coverage rates (VCR) is available, though with a delay in data availability. Before and after the pandemic, individuals aged 50-59 had the highest rates of influenza-related hospitalization and ICU admission compared to younger age groups. Across all age groups and seasons, individuals with UC experienced higher rates of medically attended influenza cases, hospitalizations, and healthcare costs, with those aged 35-59 being particularly vulnerable. Vaccine coverage was higher in adults aged 35-59 compared to those aged 18-24, and in females compared to males.

Limitations: Discrepancies of vaccination status, limited data availability, and variations among the extent of UCs.

Conclusion: In Germany, recent policy measures have mainly targeted those aged 60 and above. While this elderly population experiences the highest disease-related impact, influenza can also lead to substantial healthcare resource utilization (HCRU) and costs in younger populations with chronic UCs; Facilitating vaccination access for this group, such as through pharmacies, is essential. Definition of quantifiable vaccination targets and measures to increase vaccination rates based on these targets are required.

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来源期刊
Journal of Medical Economics
Journal of Medical Economics HEALTH CARE SCIENCES & SERVICES-MEDICINE, GENERAL & INTERNAL
CiteScore
4.50
自引率
4.20%
发文量
122
期刊介绍: Journal of Medical Economics'' mission is to provide ethical, unbiased and rapid publication of quality content that is validated by rigorous peer review. The aim of Journal of Medical Economics is to serve the information needs of the pharmacoeconomics and healthcare research community, to help translate research advances into patient care and be a leader in transparency/disclosure by facilitating a collaborative and honest approach to publication. Journal of Medical Economics publishes high-quality economic assessments of novel therapeutic and device interventions for an international audience
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