早期胃癌白球外观与临床病理特征的相关性

IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gut and Liver Pub Date : 2024-10-08 DOI:10.5009/gnl240097
Dae Jin Jung, Gwang Ha Kim, Kyungbin Kim, Hye Kyung Jeon, Dong Chan Joo, Moon Won Lee, Bong Eun Lee
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引用次数: 0

摘要

背景/目的:放大内镜窄带成像(ME-NBI)可观察到胃肠道内详细的微表面(MS)和微血管(MV)结构。白球外观(WGA)是在早期胃癌(EGC)的 ME-NBI 检查中发现的一种小的白色病变,呈球状。本研究旨在探讨EGC患者的WGA、临床病理特征和其他ME-NBI结果之间的关联:前瞻性收集并回顾性分析了122例经内镜诊断为EGC的患者(126个病灶)在内镜或手术切除前接受ME-NBI检查时是否存在WGA。在 ME-NBI 过程中,对 MS 和 MV 模式以及是否存在 WGA 和白色不透明物质 (WOS) 进行了调查。EGC病例被分为分化型和未分化型,以及粘膜型、粘膜下型和晚期型:结果:在126个病灶中,有25个(19.8%)观察到WGA。WGA与肿瘤大小(≤2 cm [17/63, 27.0%] vs >2 cm [8/63, 12.7%]; p=0.044)、组织学类型(分化型 [22/89, 24.7%]vs未分化型[3/37. 8.1%];P=0.033)和肿瘤位置(上三分之一[1/11,9.1%]vs中三分之一[18/58,31.0%]和下三分之一[6/57,10.5%];P=0.017)。虽然在椭圆形/管状MS型、细网MV型和无WOS的病灶中更常观察到WGA,但差异无统计学意义(分别为MS型,p=0.358;MV型,p=0.212;WOS,p=0.121):结论:WGA与肿瘤体积小、分化型组织学和肿瘤位置居中有关,且更常出现在具有椭圆形/管状MS和细网状MV形态以及无WOS的病灶中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer.

Background/aims: Magnifying endoscopy with narrow-band imaging (ME-NBI) enables the visualization of detailed microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. White globe appearance (WGA) is a small whitish lesion with a globular shape identified during ME-NBI for early gastric cancer (EGC). This study aimed to investigate the associations between WGA, clinicopathological characteristics, and other ME-NBI findings in patients with EGC.

Methods: The presence or absence of WGA in 122 patients (126 lesions) with an endoscopic diagnosis of EGC who underwent ME-NBI before endoscopic or surgical resection was prospectively collected and retrospectively analyzed. During ME-NBI, the MS and MV patterns and the presence of WGA and white opaque substances (WOS) were investigated. EGC cases were categorized as differentiated or undifferentiated type, and mucosal, submucosal, or advanced.

Results: Of 126 lesions, WGA was observed in 25 (19.8%). WGA was associated with tumor size (≤2 cm [17/63, 27.0%] vs >2 cm [8/63, 12.7%]; p=0.044), histologic type (differentiated type [22/89, 24.7%] vs undifferentiated type [3/37. 8.1%]; p=0.033), and tumor location (upper third [1/11, 9.1%] vs middle third [18/58, 31.0%] and lower third [6/57, 10.5%]; p=0.017). Although WGA was observed more frequently in lesions with an oval/tubular MS pattern, a fine-network MV pattern, and the absence of WOS, the difference was not statistically significant (MS pattern, p=0.358; MV pattern, p=0.212; WOS, p=0.121, respectively).

Conclusions: WGA was associated with small tumor size, differentiated-type histology, and middle-third tumor location, and was more frequently observed in lesions with an oval/tubular MS and fine-network MV patterns and the absence of WOS.

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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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