无认知障碍的进行性低渗性帕金森病的功能活动、功能连接和复杂网络生物标志物:静息态 fMRI 研究的证据。

IF 4.1 2区 医学 Q2 GERIATRICS & GERONTOLOGY
Frontiers in Aging Neuroscience Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1455020
Lei Geng, Wenfei Cao, Juan Zuo, Hongjie Yan, Jinxin Wan, Yi Sun, Nizhuan Wang
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引用次数: 0

摘要

背景:嗅觉功能障碍是帕金森病(PD)初期最常见的非运动症状之一。然而,帕金森病患者嗅觉障碍的复杂机制仍然难以捉摸:本研究收集了 30 名帕金森病患者(15 名重度嗅觉减退患者(PD-SH)和 15 名无/轻度嗅觉减退患者(PD-N/MH))和 15 名健康对照组(HC)的 rs-fMRI 数据。为了研究功能分隔,研究人员使用了低频波动幅度(ALFF)和区域同质性(ReHo)。功能连通性(FC)分析用于探索不同脑区之间的功能整合。此外,还采用了基于图论的网络分析来评估帕金森病患者的功能网络。此外,我们还进行了皮尔逊相关分析,以深入研究嗅觉功能障碍的严重程度与各种功能指标之间的关系:结果:我们发现三组患者在ALFF、ReHo、FC和拓扑脑网络属性方面存在明显差异,其中一些差异与嗅觉评分存在相关性:我们的研究利用 fMRI 分析了 PD-SH、PD-N/MH 和 HC 组的大脑功能,发现 PD-SH 和 PD-N/MH 组的分离和整合功能受损。我们假设,颞叶、额叶、枕叶和小脑活动的变化,以及小脑-半岛连接异常、节点度和节点间差异,可能与帕金森病患者的嗅觉功能障碍有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional activity, functional connectivity and complex network biomarkers of progressive hyposmia Parkinson's disease with no cognitive impairment: evidences from resting-state fMRI study.

Background: Olfactory dysfunction stands as one of the most prevalent non-motor symptoms in the initial stage of Parkinson's disease (PD). Nevertheless, the intricate mechanisms underlying olfactory deficits in Parkinson's disease still remain elusive.

Methods: This study collected rs-fMRI data from 30 PD patients [15 with severe hyposmia (PD-SH) and 15 with no/mild hyposmia (PD-N/MH)] and 15 healthy controls (HC). To investigate functional segregation, the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were utilized. Functional connectivity (FC) analysis was performed to explore the functional integration across diverse brain regions. Additionally, the graph theory-based network analysis was employed to assess functional networks in PD patients. Furthermore, Pearson correlation analysis was conducted to delve deeper into the relationship between the severity of olfactory dysfunction and various functional metrics.

Results: We discovered pronounced variations in ALFF, ReHo, FC, and topological brain network attributes across the three groups, with several of these disparities exhibiting a correlation with olfactory scores.

Conclusion: Using fMRI, our study analyzed brain function in PD-SH, PD-N/MH, and HC groups, revealing impaired segregation and integration in PD-SH and PD-N/MH. We hypothesize that changes in temporal, frontal, occipital, and cerebellar activities, along with aberrant cerebellum-insula connectivity and node degree and betweenness disparities, may be linked to olfactory dysfunction in PD patients.

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来源期刊
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES
CiteScore
6.30
自引率
8.30%
发文量
1426
期刊介绍: Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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