自闭症谱系障碍在不同年龄阶段的全脑结构和功能变化。

IF 6 2区 医学 Q1 PEDIATRICS
Zedong Wang, Liqin Zheng, Lijuan Yang, Shunjie Yin, Shiqi Yu, Kai Chen, Tao Zhang, Hesong Wang, Tao Zhang, Yong Zhang
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引用次数: 0

摘要

自闭症谱系障碍(ASD)是一种涉及区域性变化和局部神经紊乱的发育障碍。然而,很少有研究调查不同年龄阶段的功能障碍现象。本研究探讨了自闭症患者在不同发育阶段的大脑结构和功能变化,重点关注儿童期(6-12 岁)、青春期(12-18 岁)和成年期(18 岁以上)。我们使用了一套全面的神经成像指标,包括调制和非调制体素形态测量(VBM)、区域同质性(ReHo)、低频波动幅度(ALFF)和分数 ALFF(fALFF),在 VBM 和功能测量中发现了显著的特定阶段性改变。我们的研究结果表明,ASD 与大脑结构和功能的渐进性和特定阶段性异常有关,在每个发育阶段都会出现不同的模式。具体来说,我们观察到楔前、扁桃体核和下顶叶的调节性 VBM 明显减少,而中脑和颅下区域则有所增加。此外,我们还观察到包括皮状核和丘脑在内的区域出现了未调制的 VBM 增量。在功能方面,ReHo 分析表明额叶内侧回的局部同步性受到破坏,而 ALFF 和 fALFF 指标则强调了额叶下和叶下自发脑活动的改变。最后,相关性分析表明,特定阶段的研究结果与临床社交和行为相关评分密切相关,顶叶下部和普坦门的 VBM 以及补充运动区的 ReHo 与儿童期的限制性重复行为显著相关。这些发现强调了在研究 ASD 时考虑特定年龄段大脑变化的重要性,并表明在不同的发育阶段可能需要采取有针对性的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural and functional whole brain changes in autism spectrum disorder at different age stages.

Autism spectrum disorder (ASD) is a developmental disorder involving regional changes and local neural disturbances. However, few studies have investigated the dysfunctional phenomenon across different age stages. This study explores the structural and functional brain changes across different developmental stages in individuals with ASD, focusing on childhood (6-12 years), adolescence (12-18 years), and adulthood (18 + years). Using a comprehensive set of neuroimaging metrics, including modulated and non-modulated voxel-based morphometry (VBM), regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF), we identified significant stage-specific alterations in both VBM and functional measurements. Our results reveal that ASD is associated with progressive and stage-specific abnormalities in brain structure and function, with distinct patterns emerging at each developmental stage. Specifically, we observed significant modulated VBM reductions in the precuneus, lentiform nucleus, and inferior parietal lobule, accompanied by increases in the midbrain and sub-gyral regions. Moreover, we observed unmodulated VBM increment in regions including lentiform nucleus and thalamus. Functionally, ReHo analyses demonstrated disrupted local synchronization in the medial frontal gyrus, while ALFF and fALFF metrics highlighted altered spontaneous brain activity in the sub-gyral and sub-lobar. Finally, correlation analyses revealed that stage-specific findings are closely linked to clinical social- and behavior-related scores, with VBM in the inferior parietal lobule and putamen as well as ReHo in supplemental motor area being significantly associated with restrictive repetitive behaviors in childhood. These findings underscore the importance of considering age-specific brain changes when studying ASD and suggest that targeted interventions may be necessary at different developmental stages.

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来源期刊
CiteScore
12.80
自引率
4.70%
发文量
186
审稿时长
6-12 weeks
期刊介绍: European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark. European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.
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