决明子生物活性化合物综述:硅学、体外和体内研究。

IF 4.7 2区 医学 Q1 CHEMISTRY, MEDICINAL
Drug Design, Development and Therapy Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI:10.2147/DDDT.S477679
Michelle Natasha Colin, Nur Shelly Ester Claudiana, Annisa Utami Kaffah, Aliya Nur Hasanah, Sandra Megantara
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引用次数: 0

摘要

决明子是一种在许多国家都很流行的草药,人们对它的活性进行了许多研究,包括硅学、体外和体内研究。本综述将更多地关注那些具有某些药理活性的次生代谢物,这些次生代谢物经过了体内、体外和硅学测试,以确定其基本机制。目前已确定了 20 种药理活性,其中黄酮类(大黄素、山柰醇、槲皮素)是决明中最常见的次生代谢物。关于类黄酮在特定疾病中的作用的研究不胜枚举,类黄酮的检测也相当全面,因为它涵盖了三种不同的研究类型。然而,在剂型评估方面还没有取得重大进展,因此无法对抗糖、抗真菌和抗病毒等有希望的活性进行进一步研究。此外,有几种疾病缺乏全面的调查,特别是缺乏硅学研究,因此需要进一步研究以填补知识空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies.

Cassia alata Linn is a popular herbal remedy in many countries, and its activities have been studied through many studies, starting from in silico, in vitro, and in vivo. This narrative review will focus more on secondary metabolites that are responsible for certain pharmacological activities that have undergone in vivo, in vitro, and in silico testing to determine the underlying mechanism. Twenty pharmacological activities have been identified, with the flavonoid group (emodin, kaempferol, quercetin) as the most prevalent secondary metabolite found in Cassia alata. There have been numerous studies looking at the role of flavonoids about specific diseases, and flavonoid testing is quite thorough because it covers three different study types. However, there has not been significant progress accomplished in terms of the evaluation of the dosage form so that test results for promising activities like antidiabetic, antifungal, and antiviral can be carried out into further research. Additionally, several disorders lack comprehensive investigation, particularly in silico studies, therefore further study is required to fill any gaps in the knowledge.

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来源期刊
Drug Design, Development and Therapy
Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY
CiteScore
9.00
自引率
0.00%
发文量
382
审稿时长
>12 weeks
期刊介绍: Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.
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