下一代脊髓损伤临床试验：经验教训与未来成功的机遇。

IF 9.7 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

EBioMedicine Pub Date : 2024-10-08 DOI:10.1016/j.ebiom.2024.105381

Paulina S Scheuren, John L K Kramer

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引用次数: 0

摘要

尽管基础科学的发现前景广阔，临床试验也在激增，但人们对恢复脊髓损伤后神经功能的有效治疗方法的探索仍然滞后。虽然从传统意义上讲 "失败 "了，但针对长期挑战的新兴解决方案代表着迈向未来有效干预的充满希望的步伐。在这篇个人观点中，我们重点介绍了实施新解决方案的临床试验及其对该领域的影响。我们的观点是，将共享知识、适应性设计和对脊髓损伤复杂性的更深入了解结合起来，最终有望实现重大突破，从而改善脊髓损伤患者的治疗效果。

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Next-gen spinal cord injury clinical trials: lessons learned and opportunities for future success.

Despite promising basic science discoveries and a surge in clinical trials, the quest for effective treatments that restore neurological function after spinal cord injury lags on. While "failed" in a conventional sense, emerging solutions to longstanding challenges represent promising steps towards a future with effective interventions. In this personal view, we highlight clinical trials implementing new solutions and their impact on the field. Our perspective is that, ultimately, the integration of shared knowledge, adaptive designs, and a deeper understanding of the intricacies of spinal cord injury holds promise of unlocking of major breakthroughs, leading to improved outcomes for people with spinal cord injury.

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来源期刊

EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

17.70

自引率

0.90%

发文量

579

审稿时长

5 weeks

期刊介绍： eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.