{"title":"使用光学相干断层扫描(OCT)和 OCT 血管造影术评估第一剂 Sinovac 疫苗对视网膜、脉络膜和视盘的早期影响。","authors":"Yelda Yildiz Tasci, Mehmet Icoz, Sule Gokcek Gurturk Icoz, Ozge Saritas, Mucella Arikan Yorgun, Yasin Toklu","doi":"10.1080/15569527.2024.2408683","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To determine the effects of the first-dose administration of the Sinovac vaccine on the retina, choroid, and optic disc in healthy participants.</p><p><strong>Methods: </strong>This prospective design study was conducted with 27 healthy healthcare workers who received the first dose of Sinovac vaccine and 25 healthy controls who were not vaccinated. In the vaccinated group, ophthalmological examinations and measurements were performed before vaccination and one week and one month after vaccination. Subfoveal, nasal, and temporal choroidal thicknesses (CTs), retinal nerve fiber layer (RNFL) thickness, and macular thickness (MT) were determined using spectral domain-optical coherence tomography at all visits. Superficial, deep, and peripapillary radial capillary plexus (superficial capillary plexus, deep capillary plexus (DCP), and radial peripapillary capillary, respectively), choriocapillaris vascular density, and foveal avascular zone parameters were measured on optical coherence tomography-angiography (OCT-A).</p><p><strong>Results: </strong>No significant difference was detected between the two groups in terms of the parameters measured by OCT and OCT-A (<i>p</i> > 0.05 for all). The CT values measured in all quadrants were significantly higher at the first week after vaccination (<i>p</i> < 0.05 for all), and they returned to their pre-vaccination values at the first month post-vaccination measurement (<i>p</i> > 0.05 for all). Concerning the RNFL and MT values, there was no significant difference between the pre-vaccination and post-vaccination first-week measurements (<i>p</i> > 0.05 for all), but a statistically significant increase was detected in the post-vaccination first-month MT and RNFL measurements (<i>p</i> < 0.05 for all). Only the decreases in the foveal DCP and choriocapillaris vascular density values were significant at the first week after vaccination (<i>p</i> < 0.05 for all).</p><p><strong>Conclusion: </strong>The early changes detected after vaccination in this study suggest the possibility that autoimmune, vascular, and inflammatory diseases may simultaneously emerge in the early post-vaccination period or may be triggered after vaccination, or that the vaccine may unmask these diseases.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the early effects of the first-dose administration of the Sinovac vaccine on the retina, choroid, and optic disc using optical coherence tomography (OCT) and OCT-angiography.\",\"authors\":\"Yelda Yildiz Tasci, Mehmet Icoz, Sule Gokcek Gurturk Icoz, Ozge Saritas, Mucella Arikan Yorgun, Yasin Toklu\",\"doi\":\"10.1080/15569527.2024.2408683\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To determine the effects of the first-dose administration of the Sinovac vaccine on the retina, choroid, and optic disc in healthy participants.</p><p><strong>Methods: </strong>This prospective design study was conducted with 27 healthy healthcare workers who received the first dose of Sinovac vaccine and 25 healthy controls who were not vaccinated. In the vaccinated group, ophthalmological examinations and measurements were performed before vaccination and one week and one month after vaccination. Subfoveal, nasal, and temporal choroidal thicknesses (CTs), retinal nerve fiber layer (RNFL) thickness, and macular thickness (MT) were determined using spectral domain-optical coherence tomography at all visits. Superficial, deep, and peripapillary radial capillary plexus (superficial capillary plexus, deep capillary plexus (DCP), and radial peripapillary capillary, respectively), choriocapillaris vascular density, and foveal avascular zone parameters were measured on optical coherence tomography-angiography (OCT-A).</p><p><strong>Results: </strong>No significant difference was detected between the two groups in terms of the parameters measured by OCT and OCT-A (<i>p</i> > 0.05 for all). The CT values measured in all quadrants were significantly higher at the first week after vaccination (<i>p</i> < 0.05 for all), and they returned to their pre-vaccination values at the first month post-vaccination measurement (<i>p</i> > 0.05 for all). Concerning the RNFL and MT values, there was no significant difference between the pre-vaccination and post-vaccination first-week measurements (<i>p</i> > 0.05 for all), but a statistically significant increase was detected in the post-vaccination first-month MT and RNFL measurements (<i>p</i> < 0.05 for all). Only the decreases in the foveal DCP and choriocapillaris vascular density values were significant at the first week after vaccination (<i>p</i> < 0.05 for all).</p><p><strong>Conclusion: </strong>The early changes detected after vaccination in this study suggest the possibility that autoimmune, vascular, and inflammatory diseases may simultaneously emerge in the early post-vaccination period or may be triggered after vaccination, or that the vaccine may unmask these diseases.</p>\",\"PeriodicalId\":11023,\"journal\":{\"name\":\"Cutaneous and Ocular Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cutaneous and Ocular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15569527.2024.2408683\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutaneous and Ocular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569527.2024.2408683","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:确定首剂接种 Sinovac 疫苗对健康参与者视网膜、脉络膜和视盘的影响:这项前瞻性设计研究的对象是接种第一剂 Sinovac 疫苗的 27 名健康医护人员和未接种疫苗的 25 名健康对照者。接种组在接种前、接种后一周和一个月分别进行了眼科检查和测量。在所有检查中都使用光谱域光学相干断层扫描测定了眼底、鼻腔和颞部脉络膜厚度(CT)、视网膜神经纤维层厚度(RNFL)和黄斑厚度(MT)。光学相干断层扫描-血管造影(OCT-A)测量了浅层、深层和桡侧毛细血管丛(分别为浅层毛细血管丛、深层毛细血管丛(DCP)和桡侧毛细血管丛)、绒毛膜血管密度和眼窝无血管区参数:结果:两组的 OCT 和 OCT-A 测量参数无明显差异(均 p > 0.05)。接种疫苗后第一周,所有象限的 CT 值均明显升高(P 均 > 0.05)。至于 RNFL 和 MT 值,接种前和接种后第一周的测量值之间没有明显差异(均 p > 0.05),但在接种后第一个月的 MT 和 RNFL 测量值中发现了统计学意义上的显著增加(p p 结论):本研究在接种疫苗后发现的早期变化表明,自身免疫性、血管性和炎症性疾病可能在接种疫苗后的早期同时出现,或在接种疫苗后诱发,或疫苗可能掩盖这些疾病。
Evaluation of the early effects of the first-dose administration of the Sinovac vaccine on the retina, choroid, and optic disc using optical coherence tomography (OCT) and OCT-angiography.
Aim: To determine the effects of the first-dose administration of the Sinovac vaccine on the retina, choroid, and optic disc in healthy participants.
Methods: This prospective design study was conducted with 27 healthy healthcare workers who received the first dose of Sinovac vaccine and 25 healthy controls who were not vaccinated. In the vaccinated group, ophthalmological examinations and measurements were performed before vaccination and one week and one month after vaccination. Subfoveal, nasal, and temporal choroidal thicknesses (CTs), retinal nerve fiber layer (RNFL) thickness, and macular thickness (MT) were determined using spectral domain-optical coherence tomography at all visits. Superficial, deep, and peripapillary radial capillary plexus (superficial capillary plexus, deep capillary plexus (DCP), and radial peripapillary capillary, respectively), choriocapillaris vascular density, and foveal avascular zone parameters were measured on optical coherence tomography-angiography (OCT-A).
Results: No significant difference was detected between the two groups in terms of the parameters measured by OCT and OCT-A (p > 0.05 for all). The CT values measured in all quadrants were significantly higher at the first week after vaccination (p < 0.05 for all), and they returned to their pre-vaccination values at the first month post-vaccination measurement (p > 0.05 for all). Concerning the RNFL and MT values, there was no significant difference between the pre-vaccination and post-vaccination first-week measurements (p > 0.05 for all), but a statistically significant increase was detected in the post-vaccination first-month MT and RNFL measurements (p < 0.05 for all). Only the decreases in the foveal DCP and choriocapillaris vascular density values were significant at the first week after vaccination (p < 0.05 for all).
Conclusion: The early changes detected after vaccination in this study suggest the possibility that autoimmune, vascular, and inflammatory diseases may simultaneously emerge in the early post-vaccination period or may be triggered after vaccination, or that the vaccine may unmask these diseases.
期刊介绍:
Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures.
In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.