烟酰胺腺嘌呤二核苷酸(NAD)依赖性蛋白去乙酰化酶 Sirtuin 作为健康寿命的生物标志物:微型综述。

Q3 Medicine
Yodo Sugishita, Yuki Suzuki-Takahashi, Kazuo Yudoh
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引用次数: 0

摘要

虽然针对常见的生活方式或与衰老有关的疾病已确定了多种疾病特异性生物标志物,但目前还没有指数可用于衡量总体健康状况或各种组织和器官损伤的症状前状态。越来越多的研究表明,sirtuins 有可能被用作评估总体健康状况和是否存在症状前疾病状态的指标。Sirtuins(SIRTs)是一种依赖于烟酰胺腺嘌呤二核苷酸(NAD)的去乙酰化酶,在人类各种体细胞中均有表达,包括在健康和疾病状态下。SIRTs 的活性和表达影响重要的代谢途径,如细胞存活、衰老、增殖、能量产生、应激耐受、DNA 修复和细胞凋亡,从而与衰老和长寿密切相关。鉴于 SIRTs 在维持生理功能方面的广泛意义,它们在体细胞中的活性可能反映出衰老或全身炎症反应引起的组织损伤的早期横断面状态,而这些损伤还无法通过疾病特异性生物标志物检测出来。在这篇微型综述中,我们将讨论 SIRTs 作为健康状况的替代临床生物标志物的效用,以评估和监测健康预期寿命和症状前疾病状态的存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini-Review.

Although a variety of disease-specific biomarkers have been identified for common lifestyle- or aging-related diseases, there are currently no indices available to measure general health or the existence of pre-symptomatic conditions in various types of tissue and organ damage. A rising body of research suggests that sirtuins may have the potential to be used as an index to assess overall health status and the existence of pre-symptomatic illness states. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases expressed in a variety of human somatic cells both in health and disease conditions. The activity and expression of SIRTs affect important metabolic pathways, such as cell survival, senescence, proliferation, energy production, stress tolerance, DNA repair, and apoptosis, thereby closely linked to aging and longevity. Given the broad significance of SIRTs in physiological function maintenance, their activity in somatic cells may reflect the early cross-sectional status of tissue damage caused by aging or systemic inflammatory responses that are too early to be detected by disease-specific biomarkers. In this mini-review, we discuss the utility of SIRTs as a surrogate clinical biomarker for health status to evaluate and monitor health life expectancy and the presence of pre-symptomatic illness states.

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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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